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Background <p>The widespread adoption of glucagon-like peptide-1 (GLP-1) receptor agonists has generated a new cohort of weight loss patients seeking aesthetic surgery. Their psychosocial characteristics and aesthetic expectations, compared with traditional post-bariatric patients, remain poorly defined.</p> Objectives <p>To compare psychosocial well-being, body image, and satisfaction in female patients undergoing body contouring after GLP-1–induced versus bariatric weight loss.</p> Methods <p>A single-center, prospective pilot comparative study including women only was conducted. Of 82 enrolled patients, 72 completed follow-up and were analyzed (GLP-1: n = 38; post-bariatric: n = 34). The prespecified primary endpoint was the change in BODY-Q Satisfaction with Body score from baseline (T0) to 6 months (T6). Secondary endpoints included other BODY-Q domains and, when applicable, FACE-Q and Wrinkle Severity Rating Scale (WSRS) measures. Validated patient-reported outcome measures (PROMs) were administered at T0 and T6.</p> Results <p>Both cohorts demonstrated significant improvement in Satisfaction with Body from T0 to T6 (GLP-1: 43.1 ± 12.5 → 72.8 ± 13.9; Δ = 29.7; p &lt; 0.001; post-bariatric: 39.6 ± 11.7 → 68.5 ± 14.7; Δ = 28.9; p &lt; 0.001), with no between-group difference in improvement (p = 0.67). GLP-1 patients showed higher preoperative scores but greater emotional reactivity to residual contour irregularities. In the facial subgroup (n = 21), FACE-Q improved and WSRS decreased similarly across groups. Multivariable analysis revealed no independent effect of weight loss modality on BODY-Q change (β = 0.12; p = 0.58); lower baseline psychosocial scores predicted postoperative dissatisfaction (β = −0.34; p = 0.02).</p> Conclusions <p>Body contouring after GLP-1–induced weight loss yields psychosocial and aesthetic benefits comparable to those achieved after bariatric surgery, yet GLP-1 patients exhibit distinct preoperative expectations and heightened emotional sensitivity to imperfections. Despite the female-only, single-center pilot design, these findings underscore the importance of tailored counseling and highlight the need for larger multicenter studies to refine patient selection and expectation management.</p> Level of Evidence II <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

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Psychosocial Outcomes and Aesthetic Expectations in Female Patients Undergoing Body Contouring After GLP-1–Induced Weight Loss: A Prospective Pilot Comparative Study with Post-Bariatric Patients

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Martina Ponzo,
  • Mariagiovanna Lombardi,
  • Adriano Santorelli

摘要

Background

The widespread adoption of glucagon-like peptide-1 (GLP-1) receptor agonists has generated a new cohort of weight loss patients seeking aesthetic surgery. Their psychosocial characteristics and aesthetic expectations, compared with traditional post-bariatric patients, remain poorly defined.

Objectives

To compare psychosocial well-being, body image, and satisfaction in female patients undergoing body contouring after GLP-1–induced versus bariatric weight loss.

Methods

A single-center, prospective pilot comparative study including women only was conducted. Of 82 enrolled patients, 72 completed follow-up and were analyzed (GLP-1: n = 38; post-bariatric: n = 34). The prespecified primary endpoint was the change in BODY-Q Satisfaction with Body score from baseline (T0) to 6 months (T6). Secondary endpoints included other BODY-Q domains and, when applicable, FACE-Q and Wrinkle Severity Rating Scale (WSRS) measures. Validated patient-reported outcome measures (PROMs) were administered at T0 and T6.

Results

Both cohorts demonstrated significant improvement in Satisfaction with Body from T0 to T6 (GLP-1: 43.1 ± 12.5 → 72.8 ± 13.9; Δ = 29.7; p < 0.001; post-bariatric: 39.6 ± 11.7 → 68.5 ± 14.7; Δ = 28.9; p < 0.001), with no between-group difference in improvement (p = 0.67). GLP-1 patients showed higher preoperative scores but greater emotional reactivity to residual contour irregularities. In the facial subgroup (n = 21), FACE-Q improved and WSRS decreased similarly across groups. Multivariable analysis revealed no independent effect of weight loss modality on BODY-Q change (β = 0.12; p = 0.58); lower baseline psychosocial scores predicted postoperative dissatisfaction (β = −0.34; p = 0.02).

Conclusions

Body contouring after GLP-1–induced weight loss yields psychosocial and aesthetic benefits comparable to those achieved after bariatric surgery, yet GLP-1 patients exhibit distinct preoperative expectations and heightened emotional sensitivity to imperfections. Despite the female-only, single-center pilot design, these findings underscore the importance of tailored counseling and highlight the need for larger multicenter studies to refine patient selection and expectation management.

Level of Evidence II

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.