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Background <p>Intraoral injection techniques have been reported in various countries, with their advantages well documented. Drawing upon existing literature on intraoral injections, we developed a novel intraoral submucosal zonal injection technique that has demonstrated promising therapeutic outcomes. However, its efficacy and safety require further validation through standardized clinical practice.</p> Objective <p>The aim is compare the efficacy and safety of traditional extra-oral with novel intraoral submucosal zonal injection technique for improving perioral contour and assess the clinical applicability of the intraoral technique.</p> Method <p>Fifty-two female patients (aged 24–43) with perioral aging were randomized to receive either the traditional extra-oral injection group (Group A, n=26) or the intraoral submucosal zonal injection group (Group B, n=26). Efficacy was assessed using blinded digital photographic analysis, Global Aesthetic Improvement Scale, and Wrinkle Severity Rating Scale. Patient satisfaction, procedural pain, and adverse events were monitored.</p> Result <p>Intraoral submucosal zonal injection demonstrated clinical efficacy equivalent to extra-oral injection on GAIS and WSRS assessments, while significantly improving procedural comfort. This technique showed enhanced patient-rated acceptability in perioral regions including nasolabial folds, accompanied by significantly reduced VAS pain scores and decreased adverse event incidence.</p> Conclusion <p>Compared to traditional extra-oral injection, intraoral submucosal zonal injection shows certain clinical advantages: significantly enhanced patient satisfaction and reducing the incidence of adverse reactions such as procedural pain. It can serve as an alternative option for improving perioral contour, particularly suitable for patients prioritizing comfort and minimal downtime.</p> Level of Evidence V <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

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Comparative Efficacy and Patient-centered Outcomes of Intraoral Submucosal Zonal Injection Versus Traditional Extra-oral Injection for Improving Perioral Contour: A Randomized Controlled Trial

  • 期刊论文

  • 发表日期：

    2026年3月12日

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  • Yongshu Wang,
  • Lishuai Shi,
  • Yaochen Zhang,
  • Jinjun Xiu,
  • Liuli Dai,
  • Min Yin,
  • Wei Dang,
  • Qingqing Wang,
  • Linlin Tan,
  • Haiyan Cui

摘要

Background

Intraoral injection techniques have been reported in various countries, with their advantages well documented. Drawing upon existing literature on intraoral injections, we developed a novel intraoral submucosal zonal injection technique that has demonstrated promising therapeutic outcomes. However, its efficacy and safety require further validation through standardized clinical practice.

Objective

The aim is compare the efficacy and safety of traditional extra-oral with novel intraoral submucosal zonal injection technique for improving perioral contour and assess the clinical applicability of the intraoral technique.

Method

Fifty-two female patients (aged 24–43) with perioral aging were randomized to receive either the traditional extra-oral injection group (Group A, n=26) or the intraoral submucosal zonal injection group (Group B, n=26). Efficacy was assessed using blinded digital photographic analysis, Global Aesthetic Improvement Scale, and Wrinkle Severity Rating Scale. Patient satisfaction, procedural pain, and adverse events were monitored.

Result

Intraoral submucosal zonal injection demonstrated clinical efficacy equivalent to extra-oral injection on GAIS and WSRS assessments, while significantly improving procedural comfort. This technique showed enhanced patient-rated acceptability in perioral regions including nasolabial folds, accompanied by significantly reduced VAS pain scores and decreased adverse event incidence.

Conclusion

Compared to traditional extra-oral injection, intraoral submucosal zonal injection shows certain clinical advantages: significantly enhanced patient satisfaction and reducing the incidence of adverse reactions such as procedural pain. It can serve as an alternative option for improving perioral contour, particularly suitable for patients prioritizing comfort and minimal downtime.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.