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Background and Aim <p>The present study aimed to evaluate the effectiveness of the two–three-point injection technique using hyaluronic acid fillers to increase chin volume.</p> Method <p>The present study included three RCT and three cohort studies of international databases, PubMed, Scopus, Web of Science, and Embase using relevant keywords until June 2025. The statistical analysis was performed with Stata/MP.v17 as fixed or random effect models.</p> Results <p>The GAIS responder rate for chin enhancement of HA filler with two–three-point injection technique was 94% (ES: 0.94; <i>P</i>&#xa0;&lt;&#xa0;0.001; 95% CI 0.92, 0.97). Common ISRs were firmness (ES: 91%; 95% CI 88–94%) and swelling (ES: 87%; 95% CI 84–90%). The overall rate of adverse events was estimated to be 7.92% (ES: 7.92%; 95% CI 6.31–9.53%).</p> Conclusion <p>High efficacy and acceptable safety were evident for the two–three-point injection technique for HA filler injection for the chin enhancement.</p> Level of Evidence V <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="https://www.springer.com/00266">www.springer.com/00266</a>.</p>

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Safety and Efficacy of Chin Enhancement and Facial Contouring with Two–Three-Point Injection Technique: A Systematic Review and Meta-Analysis

  • 期刊论文

  • 发表日期：

    2026年2月10日

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  • Maryam Milanifard,
  • Amir Hashemloo

摘要

Background and Aim

The present study aimed to evaluate the effectiveness of the two–three-point injection technique using hyaluronic acid fillers to increase chin volume.

Method

The present study included three RCT and three cohort studies of international databases, PubMed, Scopus, Web of Science, and Embase using relevant keywords until June 2025. The statistical analysis was performed with Stata/MP.v17 as fixed or random effect models.

Results

The GAIS responder rate for chin enhancement of HA filler with two–three-point injection technique was 94% (ES: 0.94; P < 0.001; 95% CI 0.92, 0.97). Common ISRs were firmness (ES: 91%; 95% CI 88–94%) and swelling (ES: 87%; 95% CI 84–90%). The overall rate of adverse events was estimated to be 7.92% (ES: 7.92%; 95% CI 6.31–9.53%).

Conclusion

High efficacy and acceptable safety were evident for the two–three-point injection technique for HA filler injection for the chin enhancement.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.