Scholarlink

Objective <p>Botulinum toxin type A (BTX-A) is a simple and effective method for treating drooping mouth corners. However, the effective dosage and injection sites remain controversial. The authors propose a triangular three-point injection technique and compare the effects of different dosages tailored to varying severity levels of drooping mouth corners.</p> Methods <p>Before the start of this prospective self-controlled study, subjects with drooping mouth corners received two treatment methods. First, participants received a single-point injection of 3 U of BTX-A per side. Four months later, an individualized approach was adopted, with 3–15 U of BTX-A injected at three sites per side based on severity. Data were collected at baseline and at 4- and 12-week follow-ups.</p> Results <p>Fifty-one subjects were enrolled. At 4 weeks after injection, both methods significantly improved drooping mouth corners, with the indicators returning to baseline levels by 12 weeks (<i>P </i>&lt; 0.05). Based on clinical manifestations, subjects were categorized into mild, moderate, severe, and most severe cases, receiving 3 U, 6/9 U, 9/12 U, and 12/15 U per side, respectively. The results showed that 3 U/side for mild cases, 6 U/side for moderate cases, and 12 U/side for severe cases were the safest and most effective dosages, while most severe cases still did not achieve satisfactory results even at 15 U/side. Overall, at 4 weeks post-treatment, the reduction in the vertical distance from the mouth corner to the pupillary line and the angle of drooping were significantly greater with the triangular three-point injection technique compared to the single-point injection (<i>P </i>≤ 0.05). No adverse events were observed in any subjects.</p> Conclusion <p>It is necessary to increase the injection dosage according to the severity of drooping mouth corners. The new triangular three-point injection technique is safe and demonstrates favorable clinical outcomes.</p> Level of Evidence II <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Impact of Dosage and Injection Site on Type A Botulinum Toxin Treatment for Oral Commissure Ptosis: A Prospective Study

  • 期刊论文

  • 发表日期：

    2026年2月5日

查看全文
  • Ziqing He,
  • Wenwen Xi,
  • Feng Yang

摘要

Objective

Botulinum toxin type A (BTX-A) is a simple and effective method for treating drooping mouth corners. However, the effective dosage and injection sites remain controversial. The authors propose a triangular three-point injection technique and compare the effects of different dosages tailored to varying severity levels of drooping mouth corners.

Methods

Before the start of this prospective self-controlled study, subjects with drooping mouth corners received two treatment methods. First, participants received a single-point injection of 3 U of BTX-A per side. Four months later, an individualized approach was adopted, with 3–15 U of BTX-A injected at three sites per side based on severity. Data were collected at baseline and at 4- and 12-week follow-ups.

Results

Fifty-one subjects were enrolled. At 4 weeks after injection, both methods significantly improved drooping mouth corners, with the indicators returning to baseline levels by 12 weeks (P < 0.05). Based on clinical manifestations, subjects were categorized into mild, moderate, severe, and most severe cases, receiving 3 U, 6/9 U, 9/12 U, and 12/15 U per side, respectively. The results showed that 3 U/side for mild cases, 6 U/side for moderate cases, and 12 U/side for severe cases were the safest and most effective dosages, while most severe cases still did not achieve satisfactory results even at 15 U/side. Overall, at 4 weeks post-treatment, the reduction in the vertical distance from the mouth corner to the pupillary line and the angle of drooping were significantly greater with the triangular three-point injection technique compared to the single-point injection (P ≤ 0.05). No adverse events were observed in any subjects.

Conclusion

It is necessary to increase the injection dosage according to the severity of drooping mouth corners. The new triangular three-point injection technique is safe and demonstrates favorable clinical outcomes.

Level of Evidence II

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.