Scholarlink

Background <p>Dermal fillers have become prevalent in aesthetic surgery, offering noninvasive solutions for addressing signs of aging and enhancing facial features.</p> Methods <p>In this study, the <i>in vivo</i> administration of dermal fillers, including a hyaluronic-cross-linked filler (HA-R), a PDLLA-HA combined filler (HA-PDLLA), a microparticle PDO filler (PDO), a PN filler extracted from salmon milt (PN), and pure hyaluronic acid (HA), along with PBS as a control, was evaluated over a 12&#xa0;week period.</p> Results <p>HA-R exhibited sustained volume retention, contrasting with rapid volume loss observed with PN, and gradual dissolution of PDO by week 12. Histological evaluation revealed varying inflammatory responses, with PDO showing notable alleviation of inflammation after 8 weeks. MT staining demonstrated increased collagen formation post-injection, peaking at 4 weeks for most fillers. Immunofluorescent staining highlighted the initial promotion of collagen synthesis by PDO and HA-PDLLA, followed by a subsequent decline after 8 weeks.</p> Conclusion <p>This study provided comprehensive insights into the biophysical properties and efficacy of various dermal fillers in stimulating collagen production. PDO and HA-PDLLA initially demonstrated efficacy in promoting collagen synthesis, but limitations were noted in sustaining long-term collagen production. Understanding the dynamics of filler administration and its impact on tissue response is essential for optimizing outcomes in aesthetic surgery practice.</p> No Level Assigned <p>This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluation of Bio-Stimulation Effects of Various Dermal Fillers: Hyaluronic Acid-Based Polynucleotides and Microparticle Fillers in Mouse Model

  • 期刊论文

  • 发表日期：

    2025年9月2日

查看全文
  • Nguyen Ngan Giang,
  • Le Thi Thuy Linh,
  • Trinh Thi Thuy Tien,
  • Pham Thi Nga,
  • Xin Rui Zhang,
  • Yong Xun Jin,
  • Shu Yi Zhou,
  • Han Jin Kwon,
  • Jung Ryul Ham,
  • Won Ku Lee,
  • Yeon Ju Gu,
  • Yong Hyun Lee,
  • Pham Ngoc Chien,
  • Chan Yeong Heo

摘要

Background

Dermal fillers have become prevalent in aesthetic surgery, offering noninvasive solutions for addressing signs of aging and enhancing facial features.

Methods

In this study, the in vivo administration of dermal fillers, including a hyaluronic-cross-linked filler (HA-R), a PDLLA-HA combined filler (HA-PDLLA), a microparticle PDO filler (PDO), a PN filler extracted from salmon milt (PN), and pure hyaluronic acid (HA), along with PBS as a control, was evaluated over a 12 week period.

Results

HA-R exhibited sustained volume retention, contrasting with rapid volume loss observed with PN, and gradual dissolution of PDO by week 12. Histological evaluation revealed varying inflammatory responses, with PDO showing notable alleviation of inflammation after 8 weeks. MT staining demonstrated increased collagen formation post-injection, peaking at 4 weeks for most fillers. Immunofluorescent staining highlighted the initial promotion of collagen synthesis by PDO and HA-PDLLA, followed by a subsequent decline after 8 weeks.

Conclusion

This study provided comprehensive insights into the biophysical properties and efficacy of various dermal fillers in stimulating collagen production. PDO and HA-PDLLA initially demonstrated efficacy in promoting collagen synthesis, but limitations were noted in sustaining long-term collagen production. Understanding the dynamics of filler administration and its impact on tissue response is essential for optimizing outcomes in aesthetic surgery practice.

No Level Assigned

This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies.