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Background <p>Few studies of Profhilo<sup>®</sup> for facial skin regeneration in Asian patients exist.</p> Aims <p>The efficacy and safety of Profhilo<sup>®</sup> in regenerating facial skin in Asian females were investigated in a single-center study.</p> Patients/Methods <p>Patients were treated with Profhilo<sup>®</sup> on Weeks 0 and 4 and followed up on Week 12. Assessments included three-dimensional photography, Facial Volume Loss Scale (FVLS), Wrinkle Severity Rating Scale (WSRS), superficial skin hydration, transepidermal water loss (TEWL), skin elasticity, and self-rated product tolerability.</p> Results <p>Of 30 enrolled Chinese females (aged 38.0–60.0 years), outcome data were analyzed for 28 and 26 patients at Weeks 0–4 and follow-up, respectively, aside from skin hydration (<i>N </i>=&#xa0;8 and <i>N </i>=&#xa0;6, respectively). Treatment led to a FVLS (<i>P </i>=&#xa0;0.0150), WSRS (<i>P </i>=&#xa0;0.0057), and <i>R</i>3 (“tiring effect” of the skin; <i>P</i> =&#xa0;0.0424) decrease over time, but pairwise time point comparisons for these measures were not significant (NS). A trend toward a decrease in <i>F</i>1 (elasticity) over time occurred but was NS. A statistically significant improvement in superficial skin hydration and TEWL occurred over time (<i>P</i> =&#xa0;0.0010 and <i>P</i> =&#xa0;0.0055, respectively) and, specifically, at Week 12 versus baseline (<i>P</i> =&#xa0;0.0034 and <i>P</i> =&#xa0;0.0029, respectively). Patients reported “good” product tolerability.</p> Conclusions <p>Profhilo<sup>®</sup> for facial skin regeneration was efficacious and tolerable in Chinese patients. This study contributes to the limited available clinical data with Profhilo<sup>®</sup> and Asian facial skin regeneration. Profhilo<sup>®</sup> significantly improved superficial skin hydration and transepidermal water loss in Chinese patients. Profhilo<sup>®</sup> was well tolerated in Chinese patients.</p> Level of Evidence IV <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

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Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月8日

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  • Suzanne Wei Na Cheng,
  • Shi Yu Derek Lim,
  • Clara Cigni,
  • Franco Grimolizzi,
  • Chee Leok Goh

摘要

Background

Few studies of Profhilo® for facial skin regeneration in Asian patients exist.

Aims

The efficacy and safety of Profhilo® in regenerating facial skin in Asian females were investigated in a single-center study.

Patients/Methods

Patients were treated with Profhilo® on Weeks 0 and 4 and followed up on Week 12. Assessments included three-dimensional photography, Facial Volume Loss Scale (FVLS), Wrinkle Severity Rating Scale (WSRS), superficial skin hydration, transepidermal water loss (TEWL), skin elasticity, and self-rated product tolerability.

Results

Of 30 enrolled Chinese females (aged 38.0–60.0 years), outcome data were analyzed for 28 and 26 patients at Weeks 0–4 and follow-up, respectively, aside from skin hydration (N = 8 and N = 6, respectively). Treatment led to a FVLS (P = 0.0150), WSRS (P = 0.0057), and R3 (“tiring effect” of the skin; P = 0.0424) decrease over time, but pairwise time point comparisons for these measures were not significant (NS). A trend toward a decrease in F1 (elasticity) over time occurred but was NS. A statistically significant improvement in superficial skin hydration and TEWL occurred over time (P = 0.0010 and P = 0.0055, respectively) and, specifically, at Week 12 versus baseline (P = 0.0034 and P = 0.0029, respectively). Patients reported “good” product tolerability.

Conclusions

Profhilo® for facial skin regeneration was efficacious and tolerable in Chinese patients. This study contributes to the limited available clinical data with Profhilo® and Asian facial skin regeneration. Profhilo® significantly improved superficial skin hydration and transepidermal water loss in Chinese patients. Profhilo® was well tolerated in Chinese patients.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.