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Background <p>Liposuction is one of the most commonly performed aesthetic procedures. It carries a risk of complications, including the rare but potentially fatal fat embolism syndrome (FES). Prophylactic measures such as steroids and heparin have been suggested for preventing FES, but their effectiveness remains unclear.</p> Methods <p>This experimental study utilized 40 female Wistar albino rats randomly divided into four groups: control group (1), heparin-treated group (2), steroid-treated group (3), and a Heparin-steroid-treated group (4). Liposuction was performed using the dry technique to maximize embolism risk. Blood gas analyses and histological evaluations of lung tissues were conducted 72&#xa0;h post-procedure to assess the presence of fat embolism and inflammatory response.</p> Results <p>Statistical analysis of fat particle detection in the lungs showed that groups 2 and 4 had significantly fewer fat particles compared to the control group (there was no statistically significant difference between group 3 and the control group). For lung inflammation levels, groups 3 and 4 had significantly lower levels than the control group, but not group 2. Blood gas analysis indicated a decrease in arterial oxygen pressure (PaO<sub>2</sub>) in the control and steroid groups, whereas levels remained stable in the heparin-treated groups (<i>p</i> &lt; 0.05).</p> Conclusions <p>Prophylactic low molecular weight heparin significantly reduced fat particle presence and prevented hypoxemia in a rat model of liposuction-induced FES. Steroids reduced inflammation, but they did not improve oxygenation or reduce fat embolism occurrence. These findings suggest heparin as a viable strategy for preventing FES after liposuction.</p> No Level Assigned <p>This journal requires that authors assigna level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">http://www.springer.com/00266</a>.</p>

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The Use of Prophylactic Steroid and Heparin to Prevent Fat Embolism Syndrome After Liposuction

  • 期刊论文

  • 发表日期：

    2025年8月5日

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  • Emre İnözü,
  • Erkan Orhan,
  • Ayfer Özdemir,
  • Enver Arpacı,
  • Ayhan Cömert,
  • İbrahim Tekdemir

摘要

Background

Liposuction is one of the most commonly performed aesthetic procedures. It carries a risk of complications, including the rare but potentially fatal fat embolism syndrome (FES). Prophylactic measures such as steroids and heparin have been suggested for preventing FES, but their effectiveness remains unclear.

Methods

This experimental study utilized 40 female Wistar albino rats randomly divided into four groups: control group (1), heparin-treated group (2), steroid-treated group (3), and a Heparin-steroid-treated group (4). Liposuction was performed using the dry technique to maximize embolism risk. Blood gas analyses and histological evaluations of lung tissues were conducted 72 h post-procedure to assess the presence of fat embolism and inflammatory response.

Results

Statistical analysis of fat particle detection in the lungs showed that groups 2 and 4 had significantly fewer fat particles compared to the control group (there was no statistically significant difference between group 3 and the control group). For lung inflammation levels, groups 3 and 4 had significantly lower levels than the control group, but not group 2. Blood gas analysis indicated a decrease in arterial oxygen pressure (PaO2) in the control and steroid groups, whereas levels remained stable in the heparin-treated groups (p < 0.05).

Conclusions

Prophylactic low molecular weight heparin significantly reduced fat particle presence and prevented hypoxemia in a rat model of liposuction-induced FES. Steroids reduced inflammation, but they did not improve oxygenation or reduce fat embolism occurrence. These findings suggest heparin as a viable strategy for preventing FES after liposuction.

No Level Assigned

This journal requires that authors assigna level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266.