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Purpose <p>The objective of the present work was to evaluate the percentage of neocollagenesis induction of the Sculptra<sup>®</sup> in different forms of reconstitution.</p> Methods <p>For this, 150 male Swiss mice were used to which saline solution or reconstituted Sculptra<sup>®</sup> were applied to the back subcutaneous tissue immediately before application (0&#xa0;h), 2, 24 or 72&#xa0;h before administration and were euthanized after 15, 30 and 60 days of administration of the material in a number of 10/group/day. Their backs were removed for histological analysis and immunoexpression for alpha-smooth muscle actin (α-SMA). The data was statistically analyzed (<i>p </i>&lt; 0.05).</p> Results <p>After 30 days of administration, the Sculptra<sup>®</sup> 72&#xa0;h group showed greater collagen formation than the control (<i>p </i>= 0.016) and 0h groups (<i>p </i>= 0.023). After 60 days, the Sculptra<sup>®</sup> 24 and 72&#xa0;h groups also showed greater collagen formation than the control (<i>p </i>= 0.025) and 0&#xa0;h groups ( <i>p </i>= 0.039). After 30 days of administration, the Sculptra<sup>®</sup> 24 and 72&#xa0;h groups showed higher immunoexpression for α-SMA (<i>p </i>= 0.001), as well as after 60 days (<i>p </i>&lt; 0.001).</p> Conclusions <p>We can conclude that Sculptra<sup>®</sup> reconstituted 2, 24 and 72&#xa0;h before its application has the potential to induce collagen after 60 days. Furthermore, there is greater expression of α-SMA after reconstitution 24 and 72&#xa0;h before Sculptra<sup>®</sup> injection, after 30 and 60 days. No level of evidence is needed for Basic Science, Animal Study, Cadaver Study, and Experimental Study Articles.</p> No Level Assigned <p>This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>

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Impact of Poly-L-Lactic Acid Reconstitution on the Neocollagenesis Profile

  • 期刊论文

  • 发表日期：

    2025年6月5日

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  • Janaína Motta Guerra,
  • Maria Carolina Portela Albuquerque,
  • Clarice Lioba de Araújo,
  • Júlia Gonçalves Montenegro,
  • Diana Araújo Cunha,
  • Fabrício Bitu Sousa,
  • Paulo Goberlânio de Barros Filho,
  • Átila Vinícius Vitor Nobre

摘要

Purpose

The objective of the present work was to evaluate the percentage of neocollagenesis induction of the Sculptra® in different forms of reconstitution.

Methods

For this, 150 male Swiss mice were used to which saline solution or reconstituted Sculptra® were applied to the back subcutaneous tissue immediately before application (0 h), 2, 24 or 72 h before administration and were euthanized after 15, 30 and 60 days of administration of the material in a number of 10/group/day. Their backs were removed for histological analysis and immunoexpression for alpha-smooth muscle actin (α-SMA). The data was statistically analyzed (p < 0.05).

Results

After 30 days of administration, the Sculptra® 72 h group showed greater collagen formation than the control (p = 0.016) and 0h groups (p = 0.023). After 60 days, the Sculptra® 24 and 72 h groups also showed greater collagen formation than the control (p = 0.025) and 0 h groups ( p = 0.039). After 30 days of administration, the Sculptra® 24 and 72 h groups showed higher immunoexpression for α-SMA (p = 0.001), as well as after 60 days (p < 0.001).

Conclusions

We can conclude that Sculptra® reconstituted 2, 24 and 72 h before its application has the potential to induce collagen after 60 days. Furthermore, there is greater expression of α-SMA after reconstitution 24 and 72 h before Sculptra® injection, after 30 and 60 days. No level of evidence is needed for Basic Science, Animal Study, Cadaver Study, and Experimental Study Articles.

No Level Assigned

This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.