Background <p>This study aimed to report the clinical effectiveness advantages of absorbable dressing (PELNAC^TM) combined with physical antibacterial spray dressing in repairing secondary wounds from facial bumps.</p> Methods <p>Thirty-two patients comprising 20 in the experimental and 12 in the control group, respectively, were randomly selected. They had undergone excision or extended excision of facial bumps with wounds that could not be directly sutured. In the experimental group, after mass excision, the wounds were covered with PELNAC^TM. In the control group, secondary wounds were repaired by skin grafts or skin flaps after mass excision or extended excision. The postoperative infection rate, healing rate, average healing time, scar formation, and sensory recovery were compared between the two groups.</p> Results <p>The wound infection rate in the experimental group was significantly lower than in the control group (<i>P</i>&lt;0.05); the surgery time for the experimental group was shortened by 1.5&#xa0;h compared to the control group (<i>P</i>&lt;0.05). Four weeks after surgery, all wounds in the experimental group had healed, with a significantly higher healing rate than in the control group (<i>P</i>&lt;0.05). During follow-up, the scar scores in the experimental group were significantly lower than those in the control group (<i>P</i>&lt;0.05).</p> Conclusion <p>The combination of PELNAC^TM and physical antibacterial spray dressing in the repair of secondary wounds from facial bumps significantly reduced the incidence of wound infection, accelerated wound healing, reduced scar formation at the graft site, and minimized surgical trauma to the donor site.</p> Level of Evidence I <p>This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors <a href="http://www.springer.com/00266">www.springer.com/00266</a>.</p>