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Purpose <p>Hip fractures are frequently associated with poor functional outcomes, partly due to underlying nutritional deficiencies such as zinc deficiency. However, the role of zinc supplementation in the postoperative functional recovery of patients with hip fractures remains unclear.</p> Methods <p>This prospective observational study included 75 patients with hip fractures who were ambulatory before injury and underwent surgical treatment. The patients were allocated into a zinc supplementation group (group Z) and control group (group C). Group Z received oral zinc supplementation (50&#xa0;mg/day) from admission until two weeks postoperatively. The primary outcome was the recovery of walking ability at discharge, defined as achieving a level equal to or better than the pre-injury status. The secondary outcomes included changes in walking score (Δ walking score) and serum zinc levels. Propensity score matching was performed to reduce confounding factors, resulting in 26 matched pairs. Multivariable logistic regression analysis was performed to identify the independent predictors of functional recovery.</p> Results <p>Hypozincaemia was found in 98.7% of the patients at admission. After propensity score matching, the rate of walking ability recovery was significantly higher in group Z than in group C (61.5% vs. 26.9%, <i>p</i> &lt; 0.05). The Δ walking score was also significantly greater in group Z. The change in serum Zn level from admission to two weeks postoperatively was significantly higher in group Z. Multivariable logistic regression analysis identified zinc supplementation as the only independent predictor of walking ability recovery (odds ratio, 3.74; 95% confidence interval, 1.03–13.70; <i>p</i> &lt; 0.05).</p> Conclusions <p>Perioperative zinc supplementation was significantly associated with improved walking ability recovery after hip fracture surgery. Given its simplicity and safety, zinc supplementation might be a practical strategy for improving postoperative functional outcomes in this patient population. Further large-scale randomized controlled trials are warranted to confirm these findings.</p>

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Association between perioperative zinc supplementation and recovery of walking ability after hip fracture surgery: a propensity score-matched study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月26日

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  • Hironori Unno,
  • Takahiro Hasegawa,
  • Masayoshi Sato,
  • Gai Kobayashi,
  • Shine Tone,
  • Yohei Naito,
  • Masahiro Hasegawa

摘要

Purpose

Hip fractures are frequently associated with poor functional outcomes, partly due to underlying nutritional deficiencies such as zinc deficiency. However, the role of zinc supplementation in the postoperative functional recovery of patients with hip fractures remains unclear.

Methods

This prospective observational study included 75 patients with hip fractures who were ambulatory before injury and underwent surgical treatment. The patients were allocated into a zinc supplementation group (group Z) and control group (group C). Group Z received oral zinc supplementation (50 mg/day) from admission until two weeks postoperatively. The primary outcome was the recovery of walking ability at discharge, defined as achieving a level equal to or better than the pre-injury status. The secondary outcomes included changes in walking score (Δ walking score) and serum zinc levels. Propensity score matching was performed to reduce confounding factors, resulting in 26 matched pairs. Multivariable logistic regression analysis was performed to identify the independent predictors of functional recovery.

Results

Hypozincaemia was found in 98.7% of the patients at admission. After propensity score matching, the rate of walking ability recovery was significantly higher in group Z than in group C (61.5% vs. 26.9%, p < 0.05). The Δ walking score was also significantly greater in group Z. The change in serum Zn level from admission to two weeks postoperatively was significantly higher in group Z. Multivariable logistic regression analysis identified zinc supplementation as the only independent predictor of walking ability recovery (odds ratio, 3.74; 95% confidence interval, 1.03–13.70; p < 0.05).

Conclusions

Perioperative zinc supplementation was significantly associated with improved walking ability recovery after hip fracture surgery. Given its simplicity and safety, zinc supplementation might be a practical strategy for improving postoperative functional outcomes in this patient population. Further large-scale randomized controlled trials are warranted to confirm these findings.