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<p>Magnetic resonance imaging (MRI) and prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) are increasingly used together in patients with suspected or confirmed prostate cancer (PCa). Discordant findings are common because these modalities evaluate different biological and anatomical aspects of the disease. MRI is best suited for intraprostatic lesion detection and local staging, whereas PSMA PET/CT is superior for assessing nodal and distant metastases and may also contribute to selected diagnostic pathways. This review explains the reasons for these discrepancies, discusses their clinical implications, and provides practical guidance for interpreting and managing discordant findings.</p>

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Not always a perfect match: discrepancies between PSMA PET/CT and MRI in prostate cancer diagnosis and staging

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月24日

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  • Ana Lemos,
  • Sungmin Woo,
  • Ana Novaes,
  • Maria Lucano,
  • Jadson Oliveira,
  • Cecilia Torres,
  • Olivia Fukumori,
  • Gabriel Gouvea,
  • Rodolfo Reis,
  • Alberto Vargas,
  • Valdair Muglia

摘要

Magnetic resonance imaging (MRI) and prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) are increasingly used together in patients with suspected or confirmed prostate cancer (PCa). Discordant findings are common because these modalities evaluate different biological and anatomical aspects of the disease. MRI is best suited for intraprostatic lesion detection and local staging, whereas PSMA PET/CT is superior for assessing nodal and distant metastases and may also contribute to selected diagnostic pathways. This review explains the reasons for these discrepancies, discusses their clinical implications, and provides practical guidance for interpreting and managing discordant findings.