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Purpose <p>This study aimed to systematically compare the diagnostic performance of gallium-68–labeled fibroblast activation protein inhibitor-04 ([<sup>68</sup>Ga]-FAPI-04) and fluorine-18 fluorodeoxyglucose ([<sup>18</sup>F]-FDG) for gastric cancer staging using positron emission tomography combined with computed tomography (PET/CT) and positron emission tomography combined with magnetic resonance imaging (PET/MR).</p> Methods <p>In this single-center retrospective study, 35 patients with pathologically confirmed gastric cancer underwent sequential imaging with [<sup>68</sup>Ga]-FAPI-04 (PET/CT and PET/MR) and [<sup>18</sup>F]-FDG (PET/CT and/or PET/MR) within 48&#xa0;h. Diagnostic performance for primary tumors, lymph node metastases, and distant metastases was evaluated against histopathological results or clinical follow-up. Semi-quantitative parameters, including maximum standardized uptake value (SUV<sub>max</sub>) and target-to-background ratio (TBR), were compared across tracers and modalities.</p> Results <p>[<sup>68</sup>Ga]-FAPI-04 exhibited significantly higher SUV<sub>max</sub> and TBR than [<sup>18</sup>F]-FDG in primary tumors, lymph node and peritoneal metastases. Notably, [<sup>68</sup>Ga]-FAPI-04 maintained consistently high uptake in signet-ring cell carcinoma, a subtype where [<sup>18</sup>F]-FDG uptake was significantly lower. Both [<sup>68</sup>Ga]-FAPI-04 PET/CT and PET/MR significantly outperformed all [<sup>18</sup>F]-FDG-based modalities for metastasis detection, with no statistically significant difference in overall diagnostic efficacy between the two [<sup>68</sup>Ga]-FAPI-04 platforms. [<sup>68</sup>Ga]-FAPI-04 PET/MR achieved 100% lesion-level sensitivity for peritoneal metastases, while PET/CT yielded higher absolute SUV<sub>max</sub> values and PET/MR showed superior TBR.</p> Conclusion <p>[<sup>68</sup>Ga]-FAPI-04 outperforms [<sup>18</sup>F]-FDG in the detection of primary gastric cancer, regional lymph node metastases and peritoneal metastases, with consistently high tumor uptake in [<sup>18</sup>F]-FDG-insensitive histological subtypes including signet-ring cell carcinoma. [<sup>68</sup>Ga]-FAPI-04 PET/CT and PET/MR offer comparable overall diagnostic performance at the patient level, with no statistically significant differences observed between the two platforms and both modalities markedly improve the accuracy of gastric cancer staging.</p>

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[68Ga]-FAPI-04 outperforms [18F]-FDG in gastric cancer staging: a comparative study using PET/CT and PET/MR

  • 期刊论文

  • 发表日期：

    2026年4月20日

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  • Zhenghao Jiang,
  • Lifang Pang,
  • Yihan Yan,
  • Masong Tang,
  • Yiqiu Zhang

摘要

Purpose

This study aimed to systematically compare the diagnostic performance of gallium-68–labeled fibroblast activation protein inhibitor-04 ([68Ga]-FAPI-04) and fluorine-18 fluorodeoxyglucose ([18F]-FDG) for gastric cancer staging using positron emission tomography combined with computed tomography (PET/CT) and positron emission tomography combined with magnetic resonance imaging (PET/MR).

Methods

In this single-center retrospective study, 35 patients with pathologically confirmed gastric cancer underwent sequential imaging with [68Ga]-FAPI-04 (PET/CT and PET/MR) and [18F]-FDG (PET/CT and/or PET/MR) within 48 h. Diagnostic performance for primary tumors, lymph node metastases, and distant metastases was evaluated against histopathological results or clinical follow-up. Semi-quantitative parameters, including maximum standardized uptake value (SUVmax) and target-to-background ratio (TBR), were compared across tracers and modalities.

Results

[68Ga]-FAPI-04 exhibited significantly higher SUVmax and TBR than [18F]-FDG in primary tumors, lymph node and peritoneal metastases. Notably, [68Ga]-FAPI-04 maintained consistently high uptake in signet-ring cell carcinoma, a subtype where [18F]-FDG uptake was significantly lower. Both [68Ga]-FAPI-04 PET/CT and PET/MR significantly outperformed all [18F]-FDG-based modalities for metastasis detection, with no statistically significant difference in overall diagnostic efficacy between the two [68Ga]-FAPI-04 platforms. [68Ga]-FAPI-04 PET/MR achieved 100% lesion-level sensitivity for peritoneal metastases, while PET/CT yielded higher absolute SUVmax values and PET/MR showed superior TBR.

Conclusion

[68Ga]-FAPI-04 outperforms [18F]-FDG in the detection of primary gastric cancer, regional lymph node metastases and peritoneal metastases, with consistently high tumor uptake in [18F]-FDG-insensitive histological subtypes including signet-ring cell carcinoma. [68Ga]-FAPI-04 PET/CT and PET/MR offer comparable overall diagnostic performance at the patient level, with no statistically significant differences observed between the two platforms and both modalities markedly improve the accuracy of gastric cancer staging.