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Background <p>We aimed to evaluate the utility of 5-T Gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) by intraindividual comparison with 3-T MRI, with a focus on the image quality and diagnosis of hepatocellular carcinoma (HCC).</p> Methods <p>We prospectively enrolled 41 patients with suspected HCC who underwent dynamic Gd-EOB-DTPA-enhanced MRI using both 5-T and 3-T scanners. Artificial intelligence-assisted compressed sensing (ACS) and parallel imaging (PI) were both used for hepatobiliary phase (HBP) imaging at 5-T. Two radiologists performed qualitative and quantitative assessments of image quality and evaluations of imaging features. Wilcoxon signed-rank, paired χ<sup>2</sup>, and Cochran Q tests as well as intraclass correlation coefficients and the Cohen κ value were used.</p> Results <p>All subjective image quality scores ranged from good to excellent. The subjective scores of contrast-enhanced phases for 5-T images were higher than those for 3-T images (all <i>p</i> &lt; 0.05), except for image artifacts. For diffusion-weighted imaging (DWI), the subjective scores of the clarity of the lesion margins on 5-T images were higher than those on 3-T images (<i>p</i> = 0.021). Quantitative measures were also greater for 5-T images (all <i>p</i> &lt; 0.05). For DWI, the contrast ratio (CR) at 5-T was greater (<i>p</i> &lt; 0.05). Subjective and quantitative assessments of HBP imaging were higher with ACS (all <i>p</i> &lt; 0.05). The detection rate of enhancing capsule was greater for 5-T images (<i>p</i> = 0.016), as was the rate of peritumoral hypointensity on the HBP images at 5-T using ACS (<i>p</i> = 0.015).</p> Conclusions <p>Compared with 3-T MRI, liver dynamic Gd-EOB-DTPA-enhanced 5-T MRI demonstrated superior image quality for contrast-enhanced phases and greater sensitivity in detecting enhancing capsule in HCC. The integration of 5-T MRI and ACS technology has the potential to further improve image quality and the assessment of imaging features.</p> Relevance statement <p>Gd-EOB-DTPA-enhanced 5-T MRI provides promising potential for accurate HCC evaluation.</p>

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Intraindividual comparison of 3-T and 5-T gadoxetic acid-enhanced MRI for evaluating HCC: initial findings

  • 期刊论文

  • 发表日期：

    2026年4月10日

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  • Shaopeng Li,
  • Shuhang Liang,
  • Mengqiu Liu,
  • Xudan Chen,
  • Dawei Yin,
  • Zhichao Feng,
  • Runyu Tang,
  • Xiaopeng Song,
  • Peng Wang,
  • Ying Liu,
  • Lianxin Liu

摘要

Background

We aimed to evaluate the utility of 5-T Gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) by intraindividual comparison with 3-T MRI, with a focus on the image quality and diagnosis of hepatocellular carcinoma (HCC).

Methods

We prospectively enrolled 41 patients with suspected HCC who underwent dynamic Gd-EOB-DTPA-enhanced MRI using both 5-T and 3-T scanners. Artificial intelligence-assisted compressed sensing (ACS) and parallel imaging (PI) were both used for hepatobiliary phase (HBP) imaging at 5-T. Two radiologists performed qualitative and quantitative assessments of image quality and evaluations of imaging features. Wilcoxon signed-rank, paired χ2, and Cochran Q tests as well as intraclass correlation coefficients and the Cohen κ value were used.

Results

All subjective image quality scores ranged from good to excellent. The subjective scores of contrast-enhanced phases for 5-T images were higher than those for 3-T images (all p < 0.05), except for image artifacts. For diffusion-weighted imaging (DWI), the subjective scores of the clarity of the lesion margins on 5-T images were higher than those on 3-T images (p = 0.021). Quantitative measures were also greater for 5-T images (all p < 0.05). For DWI, the contrast ratio (CR) at 5-T was greater (p < 0.05). Subjective and quantitative assessments of HBP imaging were higher with ACS (all p < 0.05). The detection rate of enhancing capsule was greater for 5-T images (p = 0.016), as was the rate of peritumoral hypointensity on the HBP images at 5-T using ACS (p = 0.015).

Conclusions

Compared with 3-T MRI, liver dynamic Gd-EOB-DTPA-enhanced 5-T MRI demonstrated superior image quality for contrast-enhanced phases and greater sensitivity in detecting enhancing capsule in HCC. The integration of 5-T MRI and ACS technology has the potential to further improve image quality and the assessment of imaging features.

Relevance statement

Gd-EOB-DTPA-enhanced 5-T MRI provides promising potential for accurate HCC evaluation.