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<p>The 2023 FIGO staging update for endometrial cancer moves beyond anatomy to integrate histology and molecular classification. This review outlines the new framework, illustrates its application through radiologic-pathologic case vignettes, and highlights how multidisciplinary input guides staging and therapy. Major revisions include separate substages for aggressive histologies, depth-based divisions incorporating LVSI, and molecularly driven categories such as POLE-abnormal and p53-abnormal tumors. Although these refinements sharpen prognostic accuracy, unequal access to advanced testing and interpretive variability remain obstacles to uniform implementation.</p>

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Working in concert: radiology, pathology, and gynecologic oncology applications of the 2023 FIGO updates in endometrial cancer staging

  • 期刊论文

  • 发表日期：

    2026年3月3日

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  • Wei Li,
  • Tannaz Rajabi,
  • Natalia Yanchenko,
  • Jamie Linn McDowell,
  • Ashlee L Smith,
  • Sharlin Varghese,
  • Akshya Gupta

摘要

The 2023 FIGO staging update for endometrial cancer moves beyond anatomy to integrate histology and molecular classification. This review outlines the new framework, illustrates its application through radiologic-pathologic case vignettes, and highlights how multidisciplinary input guides staging and therapy. Major revisions include separate substages for aggressive histologies, depth-based divisions incorporating LVSI, and molecularly driven categories such as POLE-abnormal and p53-abnormal tumors. Although these refinements sharpen prognostic accuracy, unequal access to advanced testing and interpretive variability remain obstacles to uniform implementation.