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Objectives <p>To assess transmural damage in Crohn’s disease (CD), magnetic resonance enterography (MRE, scored by the Magnetic Resonance Index of Activity, MaRIA) and intestinal ultrasound (IUS, scored by the International Bowel Ultrasound Segmental Activity Score, IBUS-SAS) are used. This study examined their correlation with the Crohn’s Disease Endoscopic Index of Severity (CDEIS) in children with CD.</p> Methods <p>This was a retrospective analysis of children with new-onset CD who were treated from 2017 to 2022 at Zhejiang University Children’s Hospital. The patients underwent IUS, MRE, and colonoscopy. MaRIA, IBUS-SAS, and CDEIS were assessed across intestinal segments. Correlation analyses were performed separately for the total score (all segments), as well as the terminal ileum score (terminal ileum segments) and the colon score (all colorectal segments). Nonnormally distributed data were analysed using Spearman’s rank correlation coefficient.</p> Results <p>Forty-eight children were included in this study. The total MaRIA and total IBUS-SAS scores were positively correlated with the CDEIS value (<i>r</i> = 0.334 and <i>r</i> = 0.328, both <i>p</i> &lt; 0.05). In the colorectal region, the Spearman’s rank correlation coefficient between the MaRIA score and the CDEIS value was 0.345 (<i>P</i> &lt; 0.05), and that between the IBUS-SAS score and the CDEIS value was 0.501 (<i>P</i> &lt; 0.05). However, in the terminal ileum, neither the IBUS-SAS nor the MaRIA score was significantly correlated with the CDEIS value. In the validation of the total IBUS-SAS, the AUC was 0.655 (95% CI 0.496–0.814), with an optimal cutoff value to predict endoscopically moderate active disease (CDEIS value ≥ 9) of 55.5.</p> Conclusions <p>Both the MaRIA and the IBUS-SAS correlate with CDEIS in new-onset pediatric CD. IBUS-SAS &gt; 55.5 indicates moderate activity. IUS can serve as an alternative to MRE for disease activity assessment when MRE is not viable.</p>

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Ultrasound and MRI for pediatric Crohn’s disease assessment: correlations of the MaRIA score and IBUS-SAS with endoscopic disease activity and optimal cutoff values

  • 期刊论文

  • 发表日期：

    2025年11月21日

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  • Yu Yu,
  • Bing Xu,
  • Jie Chen,
  • Hong Zhao,
  • Kerong Peng,
  • Lujing Tang,
  • Youyou Luo,
  • Xiaohui Ma

摘要

Objectives

To assess transmural damage in Crohn’s disease (CD), magnetic resonance enterography (MRE, scored by the Magnetic Resonance Index of Activity, MaRIA) and intestinal ultrasound (IUS, scored by the International Bowel Ultrasound Segmental Activity Score, IBUS-SAS) are used. This study examined their correlation with the Crohn’s Disease Endoscopic Index of Severity (CDEIS) in children with CD.

Methods

This was a retrospective analysis of children with new-onset CD who were treated from 2017 to 2022 at Zhejiang University Children’s Hospital. The patients underwent IUS, MRE, and colonoscopy. MaRIA, IBUS-SAS, and CDEIS were assessed across intestinal segments. Correlation analyses were performed separately for the total score (all segments), as well as the terminal ileum score (terminal ileum segments) and the colon score (all colorectal segments). Nonnormally distributed data were analysed using Spearman’s rank correlation coefficient.

Results

Forty-eight children were included in this study. The total MaRIA and total IBUS-SAS scores were positively correlated with the CDEIS value (r = 0.334 and r = 0.328, both p < 0.05). In the colorectal region, the Spearman’s rank correlation coefficient between the MaRIA score and the CDEIS value was 0.345 (P < 0.05), and that between the IBUS-SAS score and the CDEIS value was 0.501 (P < 0.05). However, in the terminal ileum, neither the IBUS-SAS nor the MaRIA score was significantly correlated with the CDEIS value. In the validation of the total IBUS-SAS, the AUC was 0.655 (95% CI 0.496–0.814), with an optimal cutoff value to predict endoscopically moderate active disease (CDEIS value ≥ 9) of 55.5.

Conclusions

Both the MaRIA and the IBUS-SAS correlate with CDEIS in new-onset pediatric CD. IBUS-SAS > 55.5 indicates moderate activity. IUS can serve as an alternative to MRE for disease activity assessment when MRE is not viable.