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Purpose <p>To perform an intraindividual comparison of hepatic enhancement on MRI after gadopiclenol versus gadobenate dimeglumine administration.</p> Materials and methods <p>This single-center retrospective study included 71 patients who underwent gadopiclenol-enhanced MR imaging of the liver between September 2023 and December 2023. Patients with a comparison gadobenate dimeglumine-enhanced MRI of the liver within 18 months of the gadopiclenol-enhanced study were included. Gadopiclenol was injected at 0.05 mmol/kg (0.1&#xa0;ml/kg) and gadobenate dimeglumine at 0.1 mmol/kg (0.2&#xa0;ml/kg). The signal intensity (SI) of the liver parenchyma was independently recorded by two radiologists with subspecialization in abdominal imaging on pre-contrast, 3&#xa0;min post-contrast, and 5&#xa0;min post-contrast imaging. Liver enhancement (LE) was calculated as (post-contrast SI – pre-contrast SI) / pre-contrast SI x100. Liver enhancement per ml of Gd (LE/ml) was calculated as LE/ml of contrast used. LE and LE/ml were compared using the Student’s t-test.</p> Results <p>Patients received an average of 8 ± 1.7&#xa0;ml of gadopiclenol and 16 ± 3.5&#xa0;ml of gadobenate dimeglumine. The LE at 3&#xa0;min (Reader 1, 108 ± 40% vs. 130 ± 69%; Reader 2, 106 ± 94% vs. 104 ± 61%) and 5&#xa0;min (Reader 1, 91 ± 30% vs. 100 ± 37%; Reader 2, 92 ± 37% vs. 97 ± 40%) was not significantly different (<i>P</i> &gt; 0.3) after injection of gadopiclenol and gadobenate dimeglumine. LE/ml with gadopiclenol was significantly higher than LE/ml with gadobenate dimeglumine at 3&#xa0;min (Reader 1, 14 ± 0.1% vs. 8 ± 3%; Reader 2, 14 ± 10% vs. 7 ± 3%) and 5&#xa0;min (Reader 1, 12 ± 4% vs. 6 ± 2%; Reader 2, 12 ± 5% vs. 6 ± 2%) post-contrast administration (<i>P</i> &lt; 0.001).</p> Conclusion <p>Gadopiclenol demonstrated greater enhancement efficiency per unit volume than gadobenate dimeglumine, though overall enhancement at standard doses was similar.</p>

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Intraindividual evaluation of gadopiclenol and gadobenate dimeglumine in liver MRI: impact on enhancement efficiency

  • 期刊论文

  • 发表日期：

    2025年10月23日

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  • Shiva Yagobian,
  • Senthur Thangasamy,
  • Gayathri Devi Jalluri,
  • Alessandro Furlan

摘要

Purpose

To perform an intraindividual comparison of hepatic enhancement on MRI after gadopiclenol versus gadobenate dimeglumine administration.

Materials and methods

This single-center retrospective study included 71 patients who underwent gadopiclenol-enhanced MR imaging of the liver between September 2023 and December 2023. Patients with a comparison gadobenate dimeglumine-enhanced MRI of the liver within 18 months of the gadopiclenol-enhanced study were included. Gadopiclenol was injected at 0.05 mmol/kg (0.1 ml/kg) and gadobenate dimeglumine at 0.1 mmol/kg (0.2 ml/kg). The signal intensity (SI) of the liver parenchyma was independently recorded by two radiologists with subspecialization in abdominal imaging on pre-contrast, 3 min post-contrast, and 5 min post-contrast imaging. Liver enhancement (LE) was calculated as (post-contrast SI – pre-contrast SI) / pre-contrast SI x100. Liver enhancement per ml of Gd (LE/ml) was calculated as LE/ml of contrast used. LE and LE/ml were compared using the Student’s t-test.

Results

Patients received an average of 8 ± 1.7 ml of gadopiclenol and 16 ± 3.5 ml of gadobenate dimeglumine. The LE at 3 min (Reader 1, 108 ± 40% vs. 130 ± 69%; Reader 2, 106 ± 94% vs. 104 ± 61%) and 5 min (Reader 1, 91 ± 30% vs. 100 ± 37%; Reader 2, 92 ± 37% vs. 97 ± 40%) was not significantly different (P > 0.3) after injection of gadopiclenol and gadobenate dimeglumine. LE/ml with gadopiclenol was significantly higher than LE/ml with gadobenate dimeglumine at 3 min (Reader 1, 14 ± 0.1% vs. 8 ± 3%; Reader 2, 14 ± 10% vs. 7 ± 3%) and 5 min (Reader 1, 12 ± 4% vs. 6 ± 2%; Reader 2, 12 ± 5% vs. 6 ± 2%) post-contrast administration (P < 0.001).

Conclusion

Gadopiclenol demonstrated greater enhancement efficiency per unit volume than gadobenate dimeglumine, though overall enhancement at standard doses was similar.