Purpose <p>To compare the lesion detectability of hypovascular liver metastases between 70-keV and 40-keV images from dual energy-computed tomography (CT) reconstructed with deep-learning image reconstruction (DLIR).</p> Methods <p>This multi-institutional, retrospective study included adult patients both pre- and post-treatment for gastrointestinal adenocarcinoma. All patients underwent contrast-enhanced CT with reconstruction at 40-keV and 70-keV. Liver metastases were confirmed using gadoxetic acid-enhanced magnetic resonance imaging. Four radiologists independently assessed lesion conspicuity (per-patient and per-lesion) using a 5-point scale. A radiologic technologist measured image noise, tumor-to-liver contrast, and contrast-to-noise ratio (CNR). Quantitative and qualitative results were compared between 70-keV and 40-keV images.</p> Results <p>The study included 138 patients (mean age, 69 ± 12 years; 80 men) with 208 liver metastases. Seventy-one patients had liver metastases, while 67 did not. Primary cancer sites included 68 cases of pancreas, 50 colorectal, 12 stomach, and 8 gallbladder/bile duct. No significant difference in per-patient lesion detectability was found between 70-keV images (sensitivity, 71.8–90.1%; specificity, 61.2–85.1%; accuracy, 73.9–79.7%) and 40-keV images (sensitivity, 76.1–90.1%; specificity, 53.7–82.1%; accuracy, 71.7–79.0%) (<i>p</i> = 0.18–&gt; 0.99). Similarly, no significant difference in per-lesion lesion detectability was observed between 70-keV (sensitivity, 67.3–82.2%) and 40-keV images (sensitivity, 68.8–81.7%) (<i>p</i> = 0.20–&gt; 0.99). However, Image noise was significantly higher at 40&#xa0;keV, along with greater tumor-to-liver contrast and CNRs for both hepatic parenchyma and tumors (<i>p &lt;</i> 0.01).</p> Conclusion <p>There was no significant difference in hypovascular liver metastases detectability between 70-keV and 40-keV images using the DLIR technology.</p>