Scholarlink

Purpose <p>This study aims to evaluate the diagnostic performance of the Node Reporting and Data System (Node-RADS) for assessing regional lymph node metastasis in patients with periampullary cancer, using histopathology as the reference standard.</p> Methods <p>We conducted a retrospective analysis of 50 patients who received contrast-enhanced CT and subsequent surgical resection between January 2010 and July 2024. Patient demographics, clinical characteristics, and histopathologic data were collected. The diagnostic efficacy of Node-RADS, including lymph node size and configuration (‘border’, ‘texture’ and ‘shape’) of lymph nodes. Receiver operating characteristic (ROC) curve analysis was conducted to calculate the AUC for each parameter.</p> Results <p>The patient cohort had a mean age of 61.5 years, with a predominance of males (64.0%). Among these patients, 19 (38.0%) exhibited lymph node metastasis (pN+). Node-RADS scores ≥ 3 demonstrated strong diagnostic efficacy in assessing lymph node metastasis in periampullary cancer (sensitivity: 89.5%, specificity: 71.0%, AUC: 80.2%). Compared to the conventional short-axis criterion (≥ 10&#xa0;mm), Node-RADS showed significantly superior diagnostic efficiency (<i>p</i> &lt; 0.001). The optimal cut-off for short-axis diameter was identified as 8&#xa0;mm, yielding an AUC of 76.6%. Inter-reader agreement for assessing regional lymph node metastasis in periampullary cancer using Node-RADS was substantial (κ = 0.775), indicating reliable reproducibility among radiologists.</p> Conclusions <p>The Node-RADS significantly enhances the diagnostic performance for lymph node staging in periampullary cancer. The structured and reproducible approach can provide treatment guidance and predict disease prognosis for patients with periampullary cancer.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Diagnostic performance of CT-based node reporting and data system (Node-RADS) for regional lymph node metastasis in periampullary cancer

  • 期刊论文

  • 发表日期：

    2025年7月23日

查看全文
  • Ming Chen,
  • Xufeng Zheng,
  • Yu Fang,
  • Yubin Yao,
  • Hao Ye,
  • Weiqin Hong,
  • Zhuangyong Xu,
  • Daiying Lin

摘要

Purpose

This study aims to evaluate the diagnostic performance of the Node Reporting and Data System (Node-RADS) for assessing regional lymph node metastasis in patients with periampullary cancer, using histopathology as the reference standard.

Methods

We conducted a retrospective analysis of 50 patients who received contrast-enhanced CT and subsequent surgical resection between January 2010 and July 2024. Patient demographics, clinical characteristics, and histopathologic data were collected. The diagnostic efficacy of Node-RADS, including lymph node size and configuration (‘border’, ‘texture’ and ‘shape’) of lymph nodes. Receiver operating characteristic (ROC) curve analysis was conducted to calculate the AUC for each parameter.

Results

The patient cohort had a mean age of 61.5 years, with a predominance of males (64.0%). Among these patients, 19 (38.0%) exhibited lymph node metastasis (pN+). Node-RADS scores ≥ 3 demonstrated strong diagnostic efficacy in assessing lymph node metastasis in periampullary cancer (sensitivity: 89.5%, specificity: 71.0%, AUC: 80.2%). Compared to the conventional short-axis criterion (≥ 10 mm), Node-RADS showed significantly superior diagnostic efficiency (p < 0.001). The optimal cut-off for short-axis diameter was identified as 8 mm, yielding an AUC of 76.6%. Inter-reader agreement for assessing regional lymph node metastasis in periampullary cancer using Node-RADS was substantial (κ = 0.775), indicating reliable reproducibility among radiologists.

Conclusions

The Node-RADS significantly enhances the diagnostic performance for lymph node staging in periampullary cancer. The structured and reproducible approach can provide treatment guidance and predict disease prognosis for patients with periampullary cancer.