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Purpose <p>To evaluate the diagnostic and prognostic value of quantitative <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) metabolic parameters combined with clinical indicators in patients with locally recurrent rectal cancer (LRRC).</p> Materials and methods <p>The quantitative <sup>18</sup>F-FDG PET/CT metabolic parameters and clinical indicators of all patients with suspected LRRC after curative resection of rectal or distal sigmoid colon cancer were retrospectively analyzed. The sensitivity, specificity, and accuracy of <sup>18</sup>F-FDG PET/CT metabolic parameters were assessed using receiver operating characteristic (ROC) curves. Kaplan-Meier (KM) analysis and log-rank tests were used to estimate overall survival (OS). Univariable and multivariable Cox regression models were used to determine the potential predictors of OS.</p> Results <p>A total of 92 patients were included, with 59 confirmed LRRC cases and 33 benign lesions. Among all parameters, maximum standardized uptake value (SUV<sub>max</sub>) demonstrated the highest diagnostic performance for LRRC (cut-off = 4.71&#xa0;g/mL, AUC = 0.923, sensitivity = 93.22%, specificity = 84.85%, accuracy = 90.22%). In comparison, total lesion glycolysis of the local lesion (TLG<sub>local</sub>) exhibited relatively lower efficacy (cut-off = 33&#xa0;g, AUC = 0.785, sensitivity =77.97%, specificity = 72.73%, accuracy = 76.09%). KM survival analysis revealed that TLG<sub>local</sub> &gt; 33&#xa0;g was significantly associated with shorter OS (<i>p</i> = 0.001). Multivariable Cox analysis identified TLG<sub>local</sub> &gt; 33&#xa0;g (HR = 3.62, 95% CI: 1.39–9.44, <i>p</i> = 0.008), sacral involvement (HR = 2.68, 95% CI: 1.13–6.37, <i>p</i> = 0.025), and surgical resection (HR = 0.19, 95% CI: 0.06–0.66, <i>p</i> = 0.009) as independent prognostic factors for OS.</p> Conclusion <p><sup>18</sup>F-FDG PET/CT metabolic parameters demonstrated significant diagnostic and prognostic value in the setting of suspected LRRC. SUV<sub>max</sub> exhibited the highest diagnostic accuracy for LRRC, and TLG<sub>local</sub> was an independent predictor of OS.</p> Clinical Relevance Statement <p>This study highlights the diagnostic and prognostic value of <sup>18</sup>F-FDG PET/CT metabolic parameters in locally recurrent rectal cancer (LRRC). Maximum standardized uptake value shows high diagnostic accuracy, and total lesion glycolysis of the local lesion serves as both a diagnostic and prognostic marker for risk stratification. Additionally, sacral involvement and surgical treatment are independent predictors of overall survival. These findings underscore the importance of integrating metabolic parameters into clinical practice to enhance early detection and assist in treatment decision-making for patients with suspected LRRC.</p>

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Diagnostic and prognostic value of quantitative 18F-FDG PET/CT metabolic parameters combined with clinical indicators in patients with locally recurrent rectal cancer

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • Junjie Li,
  • Yin Zhou,
  • Liu Liu,
  • Hua Pang

摘要

Purpose

To evaluate the diagnostic and prognostic value of quantitative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) metabolic parameters combined with clinical indicators in patients with locally recurrent rectal cancer (LRRC).

Materials and methods

The quantitative 18F-FDG PET/CT metabolic parameters and clinical indicators of all patients with suspected LRRC after curative resection of rectal or distal sigmoid colon cancer were retrospectively analyzed. The sensitivity, specificity, and accuracy of 18F-FDG PET/CT metabolic parameters were assessed using receiver operating characteristic (ROC) curves. Kaplan-Meier (KM) analysis and log-rank tests were used to estimate overall survival (OS). Univariable and multivariable Cox regression models were used to determine the potential predictors of OS.

Results

A total of 92 patients were included, with 59 confirmed LRRC cases and 33 benign lesions. Among all parameters, maximum standardized uptake value (SUVmax) demonstrated the highest diagnostic performance for LRRC (cut-off = 4.71 g/mL, AUC = 0.923, sensitivity = 93.22%, specificity = 84.85%, accuracy = 90.22%). In comparison, total lesion glycolysis of the local lesion (TLGlocal) exhibited relatively lower efficacy (cut-off = 33 g, AUC = 0.785, sensitivity =77.97%, specificity = 72.73%, accuracy = 76.09%). KM survival analysis revealed that TLGlocal > 33 g was significantly associated with shorter OS (p = 0.001). Multivariable Cox analysis identified TLGlocal > 33 g (HR = 3.62, 95% CI: 1.39–9.44, p = 0.008), sacral involvement (HR = 2.68, 95% CI: 1.13–6.37, p = 0.025), and surgical resection (HR = 0.19, 95% CI: 0.06–0.66, p = 0.009) as independent prognostic factors for OS.

Conclusion

18F-FDG PET/CT metabolic parameters demonstrated significant diagnostic and prognostic value in the setting of suspected LRRC. SUVmax exhibited the highest diagnostic accuracy for LRRC, and TLGlocal was an independent predictor of OS.

Clinical Relevance Statement

This study highlights the diagnostic and prognostic value of 18F-FDG PET/CT metabolic parameters in locally recurrent rectal cancer (LRRC). Maximum standardized uptake value shows high diagnostic accuracy, and total lesion glycolysis of the local lesion serves as both a diagnostic and prognostic marker for risk stratification. Additionally, sacral involvement and surgical treatment are independent predictors of overall survival. These findings underscore the importance of integrating metabolic parameters into clinical practice to enhance early detection and assist in treatment decision-making for patients with suspected LRRC.