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Introduction <p>[<sup>18</sup>F]fluorodeprenyl-D2 ([<sup>18</sup>F]F-DED) positron emission tomography (PET) imaging detects reactive astrogliosis in patients with autoimmune encephalitis (AIE) and multiple system atrophy (MSA). Although dynamic 60-min acquisitions are established, shorter static imaging protocols are desirable for severely impaired patients. This study investigated the feasibility of short static time windows for [<sup>18</sup>F]F-DED PET imaging in AIE and MSA.</p> Methods <p>Dynamic 60-min [<sup>18</sup>F]F-DED PET scans were analyzed in 20 patients with AIE, 20 patients with MSA (MSA-P/MSA-C), and 16 controls (CTRL). Disease-related lesions were manually segmented based on visually detectable positive PET-signal in AIE and MSA predilection sites (i.e. mesial temporal lobe, posterior putamen, cerebellar deep white matter), and standardized uptake value ratios (SUVr; cerebellar cortex as a reference tissue) were calculated for consecutive 10-min intervals. Advanced kinetic parameters (DVR, VTr) were derived using Logan plot and a one-tissue compartment model (1TC2k) with image-derived input functions, both applying the cerebellar cortex as a reference tissue.</p> Results <p>Static images acquired between 10 and 60&#xa0;min p.i. showed good image contrast and signal-to-noise ratio. SUVr of lesions increased over time and approached a plateau at approximately 50–60&#xa0;min p.i.. The strongest agreement between SUVr and DVR was observed between 30 and 50&#xa0;min p.i.. Late-phase SUVr outperformed kinetic parameters in discriminating lesions from healthy tissue in both AIE and MSA.</p> Conclusion <p>Short static [<sup>18</sup>F⁸ ]F-DED PET acquisitions are clinically robust for detecting neuroinflammation in AIE and MSA. A late static acquisition between 30–50&#xa0;min p.i. provides the optimal balance between accuracy and scanning efficiency.</p>

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Feasibility of short imaging protocols for [18F]fluordeprenyl-D2 PET in autoimmune encephalitis and multiple system atrophy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月28日

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  • Lisa Tagnin,
  • Julia S. Dorneich,
  • Marianthi Zeinaki,
  • Letizia Vogler,
  • Laura Sanzo,
  • Johannes S. Gnörich,
  • Sabrina Katzdobler,
  • Ilias Masouris,
  • Alexander Jäck,
  • Alexander M. Bernhardt,
  • Boris-Stephan Rauchmann,
  • Sophia Stoecklein,
  • Marcel Simmet,
  • Emanuel Joseph,
  • Simon Lindner,
  • Norman Koglin,
  • Andre Mueller,
  • Andrew W. Stephens,
  • Gérard N. Bischof,
  • Lukas K. Frontzkowski,
  • Nicolai Franzmeier,
  • Rudolf A. Werner,
  • Jonathan A. Gernert,
  • Franziska Hopfner,
  • Günter U. Höglinger,
  • Robert Perneczky,
  • Carolin Kurz,
  • Tania Kümpfel,
  • Martin Kerschensteiner,
  • Franziska S. Thaler,
  • Johannes Levin,
  • Matthias Brendel

摘要

Introduction

[18F]fluorodeprenyl-D2 ([18F]F-DED) positron emission tomography (PET) imaging detects reactive astrogliosis in patients with autoimmune encephalitis (AIE) and multiple system atrophy (MSA). Although dynamic 60-min acquisitions are established, shorter static imaging protocols are desirable for severely impaired patients. This study investigated the feasibility of short static time windows for [18F]F-DED PET imaging in AIE and MSA.

Methods

Dynamic 60-min [18F]F-DED PET scans were analyzed in 20 patients with AIE, 20 patients with MSA (MSA-P/MSA-C), and 16 controls (CTRL). Disease-related lesions were manually segmented based on visually detectable positive PET-signal in AIE and MSA predilection sites (i.e. mesial temporal lobe, posterior putamen, cerebellar deep white matter), and standardized uptake value ratios (SUVr; cerebellar cortex as a reference tissue) were calculated for consecutive 10-min intervals. Advanced kinetic parameters (DVR, VTr) were derived using Logan plot and a one-tissue compartment model (1TC2k) with image-derived input functions, both applying the cerebellar cortex as a reference tissue.

Results

Static images acquired between 10 and 60 min p.i. showed good image contrast and signal-to-noise ratio. SUVr of lesions increased over time and approached a plateau at approximately 50–60 min p.i.. The strongest agreement between SUVr and DVR was observed between 30 and 50 min p.i.. Late-phase SUVr outperformed kinetic parameters in discriminating lesions from healthy tissue in both AIE and MSA.

Conclusion

Short static [18F⁸ ]F-DED PET acquisitions are clinically robust for detecting neuroinflammation in AIE and MSA. A late static acquisition between 30–50 min p.i. provides the optimal balance between accuracy and scanning efficiency.