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Purpose <p>The suitability of the white matter centrum semiovale (CS) as a pseudo-reference region for simplified reference tissue model 2 (SRTM2) with [¹⁸F]SynVesT-1 PET has not been evaluated in youth cohorts. We aimed to assess noninvasive quantification methods and determine the minimum scan time needed in a sample of youth with mental health challenges.</p> Methods <p>Thirty-five youth participants (16–25 years old) from the Toronto Adolescent &amp; Youth cohort underwent 120-minute scans with arterial sampling. Binding potential (<i>BP</i><sub>ND</sub>) was estimated using one-tissue compartment model (1TCM) as a reference method. The SRTM2 was then applied, with <i>k</i><sub>2</sub>′ parameter either set to population average (<i>k</i><sub>2</sub> from 1TCM) or estimated individually by initial coupled fitting in a two-step procedure. Standardized uptake value ratio − 1 (SUVR − 1, 60–90 min) was compared with 1TCM-derived <i>BP</i><sub>ND</sub>. Linear regression and percent bias analyses were performed. Time stability was assessed using several truncated scans (40–100 min).</p> Results <p>CS volume (1.7 ± 0.2 mL), <i>V</i><sub>T</sub> (4.0 ± 0.6 mL/cm3) and <i>k</i><sub>2</sub> (0.031 ± 0.004 min<sup>− 1</sup>) were consistent with previously reported values. The population-based <i>k</i><sub>2</sub>′ (0.031) and SUVR − 1 closely matched 1TCM results (<i>R</i><sup>2</sup> &gt; 0.9, &lt; 5% mean bias). The coupled-<i>k</i><sub>2</sub>′ approach underestimated several regions (<i>R</i><sup>2</sup> &gt; 0.9, &gt; 10% bias in some regions). Minimum scan durations were 60 min for 1TCM, 90 min for fixed-<i>k</i><sub>2</sub>′, and ≥ 100 min for coupled-<i>k</i><sub>2</sub>′.</p> Conclusion <p>The population-based <i>k</i><sub>2</sub>′ and semiquantitative SUVR–1 provide accurate [¹⁸F]SynVesT-1 quantification in youth with diverse clinical symptoms, supporting their use as noninvasive methods, and allowing scan time reduction to 90 minutes. This will facilitate its clinical use and wider applicability.</p>

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Assessment of noninvasive quantification of [18F]SynVesT-1 with simplified reference tissue model 2 in an adolescent and youth cohort

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月5日

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  • Carme Uribe,
  • Lucas Narciso,
  • Sang Soo Cho,
  • Maia Zilberman,
  • Cassie Cote,
  • Lujia Yu,
  • Jennifer Truong,
  • Erin Dickie,
  • Yuliya Nikolova,
  • Aristotle Voineskos,
  • M. Omair Husain,
  • Stephanie Ameis,
  • Kimberly L. Desmond,
  • Neil Vasdev,
  • Isabelle Boileau,
  • Madison Aitken,
  • Carly Albaum,
  • Stephanie H. Ameis,
  • Brendan F. Andrade,
  • Isabelle Boileau,
  • Kristin Cleverley,
  • Darren B. Courtney,
  • Claire de Oliveira,
  • Andreea O. Diaconescu,
  • Erin W. Dickie,
  • Daniel Felsky,
  • George Foussias,
  • Tristan Glatard,
  • Benjamin I. Goldstein,
  • Vanessa Gonçalves,
  • Hayley Hamilton,
  • Louise Gallagher,
  • John D. Griffiths,
  • Lisa D. Hawke,
  • Muhammad Omair Husain,
  • Sean A. Kidd,
  • Nicole Kozloff,
  • Meng-Chuan Lai,
  • Stephen P. Lewis,
  • Robert D. Levitan,
  • Hsiang-Yuan Lin,
  • Yona Lunsky,
  • Yuliya S. Nikolova,
  • Alexia Polillo,
  • Martin Rotenberg,
  • Lena C. Quilty,
  • Peter Szatmari,
  • Wanda Tempelaar,
  • Shreejoy Tripathy,
  • Neil Vasdev,
  • Wei Wang,
  • Anne L. Wheeler,
  • Erica L. Vieira,
  • Aristotle N. Voineskos

摘要

Purpose

The suitability of the white matter centrum semiovale (CS) as a pseudo-reference region for simplified reference tissue model 2 (SRTM2) with [¹⁸F]SynVesT-1 PET has not been evaluated in youth cohorts. We aimed to assess noninvasive quantification methods and determine the minimum scan time needed in a sample of youth with mental health challenges.

Methods

Thirty-five youth participants (16–25 years old) from the Toronto Adolescent & Youth cohort underwent 120-minute scans with arterial sampling. Binding potential (BPND) was estimated using one-tissue compartment model (1TCM) as a reference method. The SRTM2 was then applied, with k2′ parameter either set to population average (k2 from 1TCM) or estimated individually by initial coupled fitting in a two-step procedure. Standardized uptake value ratio − 1 (SUVR − 1, 60–90 min) was compared with 1TCM-derived BPND. Linear regression and percent bias analyses were performed. Time stability was assessed using several truncated scans (40–100 min).

Results

CS volume (1.7 ± 0.2 mL), VT (4.0 ± 0.6 mL/cm3) and k2 (0.031 ± 0.004 min− 1) were consistent with previously reported values. The population-based k2′ (0.031) and SUVR − 1 closely matched 1TCM results (R2 > 0.9, < 5% mean bias). The coupled-k2′ approach underestimated several regions (R2 > 0.9, > 10% bias in some regions). Minimum scan durations were 60 min for 1TCM, 90 min for fixed-k2′, and ≥ 100 min for coupled-k2′.

Conclusion

The population-based k2′ and semiquantitative SUVR–1 provide accurate [¹⁸F]SynVesT-1 quantification in youth with diverse clinical symptoms, supporting their use as noninvasive methods, and allowing scan time reduction to 90 minutes. This will facilitate its clinical use and wider applicability.