Scholarlink

Purpose <p>To explore whether detecting local astrogliosis using [<sup>18</sup>F]fluorodeprenyl-D2 ([<sup>18</sup>F]F-DED) positron-emission-tomography (PET) uncovers and monitors inflammatory lesions in patients with anti-leucine-rich glioma-inactivated 1 antibody (LGI1-ab) associated autoimmune encephalitis (AE).</p> Methods <p>Dynamic [<sup>18</sup>F]F-DED PET scans (0–60&#xa0;min post-injection) were obtained from a cohort of 15 LGI1-AE patients, 9 of whom were re-examined during the disease course, and from 15 controls. PET quantification was performed by kinetic modelling with an image derived input function and calculation of simplified standardized uptake values (SUV). [<sup>18</sup>F]F-DED SUVr (referenced to the straight gyrus) were analyzed for LGl1-AE target regions, compared between baseline and follow-up PET scans, used to investigate asymmetry of the mesial temporal lobe (MTL), and correlated to routine clinical data.</p> Results <p>Simplified [<sup>18</sup>F]F-DED PET quantification of the 30–60&#xa0;min time-frame showed excellent agreement with kinetic modelling of the full dynamic imaging protocol. In LGI1-AE patients, [<sup>18</sup>F]F-DED SUVr values were significantly increased by 16% in the MTL (<i>p</i> = .002) and by 12% in the cerebellum (<i>p</i> = .014). [<sup>18</sup>F]F-DED signals in the MTL significantly declined during the course of the disease (mean follow-up time: 15 months, <i>p</i> = .006). MTL asymmetry (&gt; 5%) of [<sup>18</sup>F]F-DED SUVr was present in 8/15 of LGI1-AE patients compared to 1/15 controls (<i>p</i> &lt; .001) and showed marked decline between baseline and follow-up in LGI1-AE patients.</p> Conclusion <p>This pilot study shows that [<sup>18</sup>F]F-DED PET is a promising tool to monitor regional astrogliosis in LGI1-AE patients and may provide a direct read-out of this important aspect of inflammatory disease activity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

[18F]fluorodeprenyl-D2 PET can detect and monitor astrogliosis in anti-LGI1-IgG autoimmune encephalitis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月26日

查看全文
  • J. A. Gernert,
  • L. Sanzo,
  • H. Zimmermann,
  • F. S. Thaler,
  • L. Vogler,
  • J. S. Gnörich,
  • L. Tagnin,
  • S. Lindner,
  • B. Kugelmann,
  • R. Schaefer,
  • G. N. Bischof,
  • S. Katzdobler,
  • R. A. Werner,
  • G. U. Höglinger,
  • J. Levin,
  • N. Franzmeier,
  • B. Rauchmann,
  • R. Perneczky,
  • M. Kerschensteiner,
  • T. Kümpfel,
  • M. Brendel

摘要

Purpose

To explore whether detecting local astrogliosis using [18F]fluorodeprenyl-D2 ([18F]F-DED) positron-emission-tomography (PET) uncovers and monitors inflammatory lesions in patients with anti-leucine-rich glioma-inactivated 1 antibody (LGI1-ab) associated autoimmune encephalitis (AE).

Methods

Dynamic [18F]F-DED PET scans (0–60 min post-injection) were obtained from a cohort of 15 LGI1-AE patients, 9 of whom were re-examined during the disease course, and from 15 controls. PET quantification was performed by kinetic modelling with an image derived input function and calculation of simplified standardized uptake values (SUV). [18F]F-DED SUVr (referenced to the straight gyrus) were analyzed for LGl1-AE target regions, compared between baseline and follow-up PET scans, used to investigate asymmetry of the mesial temporal lobe (MTL), and correlated to routine clinical data.

Results

Simplified [18F]F-DED PET quantification of the 30–60 min time-frame showed excellent agreement with kinetic modelling of the full dynamic imaging protocol. In LGI1-AE patients, [18F]F-DED SUVr values were significantly increased by 16% in the MTL (p = .002) and by 12% in the cerebellum (p = .014). [18F]F-DED signals in the MTL significantly declined during the course of the disease (mean follow-up time: 15 months, p = .006). MTL asymmetry (> 5%) of [18F]F-DED SUVr was present in 8/15 of LGI1-AE patients compared to 1/15 controls (p < .001) and showed marked decline between baseline and follow-up in LGI1-AE patients.

Conclusion

This pilot study shows that [18F]F-DED PET is a promising tool to monitor regional astrogliosis in LGI1-AE patients and may provide a direct read-out of this important aspect of inflammatory disease activity.