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Objective <p>To evaluate if imaging findings and shear wave elastography (SWE) can differentiate between lipoma and low-to-intermediate grade liposarcoma and to assess for SWE reproducibility across different manufacturer machines.</p> Materials and methods <p>Consecutive patients referred for lipomatous soft tissue mass biopsy prospectively underwent B-mode ultrasound (US), SWE on two machines (LOGIQ-E9 and SSI-Aixplorer), and MRI. Three musculoskeletal radiologists independently scored images and gave an assessment of malignancy on a four-point scale. Inter-reader agreement was evaluated with kappa statistic (US/US + MRI) and ICC (SSI-Aixplorer velocity/stiffness; cross-machine comparisons). Diagnostic utility of shear wave velocity (SWV) was evaluated using area under receiver operating characteristic (AUROC) curve against pathology.</p> Results <p>Among 269 patients (mean age 58.8 ± 15.7&#xa0;years, 34.6% (93/269) female), 22% (59/269) of lesions were malignant. Inter-reader agreement on SSI-Aixplorer was good for velocity and stiffness with ICC 0.87 (95% CI 0.75–0.94) and 0.93 (95% CI 0.87–0.97) respectively. Agreement between machines was moderate for velocity and stiffness with ICC 0.62 (95% CI 0.53–0.69) and 0.66 (95% CI 0.58–0.73) respectively. SWV poorly predicted malignancy (AUROC 0.57, 95% CI 0.49–0.65), and failed to differentiate benign from malignant lipomatous tumours at previously defined 2.02&#xa0;m/s threshold, misclassifying 9.5% (4/42) as benign. SWV failed to further stratify radiologist grouped benign/probably benign lesions on US (AUROC 0.59, 95% CI 0.49–0.68). Using MRI to further stratify lesions classified as benign/probably benign on US with SWV ≤ 2.02&#xa0;m/s had a sensitivity of 61.8% and specificity of 80.2%.</p> Conclusion <p>SWE did not enhance diagnostic accuracy in differentiating lipoma from low-to-intermediate grade liposarcoma and lacked reproducibility across different machines.</p>

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Evaluating shear wave elastography for differentiating lipomas from low to intermediate grade liposarcomas: is it reproducible and reliable?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月2日

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  • Michelle Wei Xin Ooi,
  • Michelle Wilson,
  • Jonathan Nicholls,
  • Bill Pass,
  • Harun Gupta,
  • Elizabeth Hensor,
  • Philip Robinson

摘要

Objective

To evaluate if imaging findings and shear wave elastography (SWE) can differentiate between lipoma and low-to-intermediate grade liposarcoma and to assess for SWE reproducibility across different manufacturer machines.

Materials and methods

Consecutive patients referred for lipomatous soft tissue mass biopsy prospectively underwent B-mode ultrasound (US), SWE on two machines (LOGIQ-E9 and SSI-Aixplorer), and MRI. Three musculoskeletal radiologists independently scored images and gave an assessment of malignancy on a four-point scale. Inter-reader agreement was evaluated with kappa statistic (US/US + MRI) and ICC (SSI-Aixplorer velocity/stiffness; cross-machine comparisons). Diagnostic utility of shear wave velocity (SWV) was evaluated using area under receiver operating characteristic (AUROC) curve against pathology.

Results

Among 269 patients (mean age 58.8 ± 15.7 years, 34.6% (93/269) female), 22% (59/269) of lesions were malignant. Inter-reader agreement on SSI-Aixplorer was good for velocity and stiffness with ICC 0.87 (95% CI 0.75–0.94) and 0.93 (95% CI 0.87–0.97) respectively. Agreement between machines was moderate for velocity and stiffness with ICC 0.62 (95% CI 0.53–0.69) and 0.66 (95% CI 0.58–0.73) respectively. SWV poorly predicted malignancy (AUROC 0.57, 95% CI 0.49–0.65), and failed to differentiate benign from malignant lipomatous tumours at previously defined 2.02 m/s threshold, misclassifying 9.5% (4/42) as benign. SWV failed to further stratify radiologist grouped benign/probably benign lesions on US (AUROC 0.59, 95% CI 0.49–0.68). Using MRI to further stratify lesions classified as benign/probably benign on US with SWV ≤ 2.02 m/s had a sensitivity of 61.8% and specificity of 80.2%.

Conclusion

SWE did not enhance diagnostic accuracy in differentiating lipoma from low-to-intermediate grade liposarcoma and lacked reproducibility across different machines.