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Background <p>Intussusception in neonates and young infants is rare, with limited data to guide management.</p> Objective <p>This study aims to characterize the presentation, management, and outcomes of intussusception in infants ≤100&#xa0;days of age.</p> Materials and methods <p>Radiology reports were searched for the keyword “intussusception” in infants ≤100&#xa0;days over a 24-year period (January 1, 2000-July 31, 2024). Patient charts were reviewed, and cases with negative imaging studies were excluded. Data were analyzed for patient demographics, presenting symptoms, imaging, and management approach, including operative or non-operative interventions. Intussusceptions were classified as small bowel–small bowel (SB/SB), enteric tube–related SB/SB, or ileocolic.</p> Results <p>Of 301 charts reviewed, 124 neonates and young infants ≤100&#xa0;days of age met inclusion criteria (median age, 55&#xa0;days; range, 0–100&#xa0;days). SB/SB intussusception accounted for 94/124 cases (76%), which included 36 (38%) enteric tube-related. Most SB/SB cases were incidental findings, and only two required surgery. Management of enteric tube–related intussusceptions consisted primarily of conservative measures such as tube shortening or removal, with complete resolution and no case requiring surgery. Thirty infants (24%) had ileocolic intussusception. Air enema was attempted in 26, with a success rate of 80% (21/26) and no perforations occurred. Surgical intervention was required in 8 cases, revealing pathologic lead points in 4 cases (duplication cysts - 3; Meckel’s diverticulum - 1), corresponding to 13% of ileocolic intussusceptions.</p> Conclusion <p>SB/SB intussusceptions predominate and rarely require intervention. Ileocolic intussusception accounts for 24% of cases, with air enema proving safe and effective in most cases. Most ileocolic intussusceptions are idiopathic (87%), with pathologic lead points identified in 13%, a higher proportion than reported in older children.</p> Graphical abstract <p></p>

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Neonatal and early infant intussusception: a 24-year retrospective review from a tertiary referral center

  • 期刊论文

  • 发表日期：

    2026年5月28日

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  • Caroline Rutten,
  • Adriana Koenig,
  • Augusto Zani,
  • Alan Daneman

摘要

Background

Intussusception in neonates and young infants is rare, with limited data to guide management.

Objective

This study aims to characterize the presentation, management, and outcomes of intussusception in infants ≤100 days of age.

Materials and methods

Radiology reports were searched for the keyword “intussusception” in infants ≤100 days over a 24-year period (January 1, 2000-July 31, 2024). Patient charts were reviewed, and cases with negative imaging studies were excluded. Data were analyzed for patient demographics, presenting symptoms, imaging, and management approach, including operative or non-operative interventions. Intussusceptions were classified as small bowel–small bowel (SB/SB), enteric tube–related SB/SB, or ileocolic.

Results

Of 301 charts reviewed, 124 neonates and young infants ≤100 days of age met inclusion criteria (median age, 55 days; range, 0–100 days). SB/SB intussusception accounted for 94/124 cases (76%), which included 36 (38%) enteric tube-related. Most SB/SB cases were incidental findings, and only two required surgery. Management of enteric tube–related intussusceptions consisted primarily of conservative measures such as tube shortening or removal, with complete resolution and no case requiring surgery. Thirty infants (24%) had ileocolic intussusception. Air enema was attempted in 26, with a success rate of 80% (21/26) and no perforations occurred. Surgical intervention was required in 8 cases, revealing pathologic lead points in 4 cases (duplication cysts - 3; Meckel’s diverticulum - 1), corresponding to 13% of ileocolic intussusceptions.

Conclusion

SB/SB intussusceptions predominate and rarely require intervention. Ileocolic intussusception accounts for 24% of cases, with air enema proving safe and effective in most cases. Most ileocolic intussusceptions are idiopathic (87%), with pathologic lead points identified in 13%, a higher proportion than reported in older children.

Graphical abstract