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Background <p>The rising prevalence of paediatric liver disease, including metabolic dysfunction- associated steatotic liver disease, highlights the need for reliable, non-invasive diagnostic tools. Advanced ultrasound techniques such as shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI) offer promising alternatives to biopsy or magnetic resonance imaging, but normative paediatric values remain limited.</p> Objective <p>This study aimed to establish age-specific reference values for SWE, SWD, and ATI in healthy children and to assess potential influencing factors such as age, sex, body mass index (BMI), and fasting duration.</p> Materials and methods <p>In this retrospective study, 264 children (135 female, median age 11.5&#xa0;years) without known liver disease were selected from a cohort of 734. Each child underwent liver ultrasound using a standardized protocol with five ATI and ten SWE/SWD measurements. Only high-quality data were included. Statistical analyses examined correlations between imaging parameters and patient characteristics.</p> Results <p>The median ATI was 0.54&#xa0;dB/cm/MHz [interquartile range (IQR):0.50–0.58], SWE was 1.24&#xa0;m/s (IQR:1.14–1.33) and SWD was 11.70 (m/s)/kHz (IQR:10.84–12.13). ATI and SWD values showed significant negative correlations with age (<i>P</i> &lt; 0.001 and <i>P</i> = 0.0048, respectively). SWD also correlated negatively with BMI <i>z</i>-score (<i>P</i> &lt; 0.001) and was significantly lower in females (<i>P</i> = 0.001). SWE showed only a weak positive correlation with measurement depth (<i>P</i> = 0.0261). Fasting duration had no significant impact on any measurement.</p> Conclusion <p>This study provides reference values for SWE, SWD, and ATI in children. Age and sex influence SWD and ATI values, underscoring the importance of age-specific interpretation in paediatric liver ultrasound.</p> Graphical Abstract <p></p>

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Reference values for shear wave elastography, shear wave dispersion and attenuation imaging in healthy paediatric livers

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月1日

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  • Michael Zellner,
  • Magdalena Schmidt,
  • Florian Huber,
  • Catherine Mary Paverd,
  • Alexander Martin,
  • Srdjan Micic,
  • André Eichenberger,
  • Vasiliki Spyropoulou,
  • Karla Drommelschmidt,
  • Christian J. Kellenberger

摘要

Background

The rising prevalence of paediatric liver disease, including metabolic dysfunction- associated steatotic liver disease, highlights the need for reliable, non-invasive diagnostic tools. Advanced ultrasound techniques such as shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI) offer promising alternatives to biopsy or magnetic resonance imaging, but normative paediatric values remain limited.

Objective

This study aimed to establish age-specific reference values for SWE, SWD, and ATI in healthy children and to assess potential influencing factors such as age, sex, body mass index (BMI), and fasting duration.

Materials and methods

In this retrospective study, 264 children (135 female, median age 11.5 years) without known liver disease were selected from a cohort of 734. Each child underwent liver ultrasound using a standardized protocol with five ATI and ten SWE/SWD measurements. Only high-quality data were included. Statistical analyses examined correlations between imaging parameters and patient characteristics.

Results

The median ATI was 0.54 dB/cm/MHz [interquartile range (IQR):0.50–0.58], SWE was 1.24 m/s (IQR:1.14–1.33) and SWD was 11.70 (m/s)/kHz (IQR:10.84–12.13). ATI and SWD values showed significant negative correlations with age (P < 0.001 and P = 0.0048, respectively). SWD also correlated negatively with BMI z-score (P < 0.001) and was significantly lower in females (P = 0.001). SWE showed only a weak positive correlation with measurement depth (P = 0.0261). Fasting duration had no significant impact on any measurement.

Conclusion

This study provides reference values for SWE, SWD, and ATI in children. Age and sex influence SWD and ATI values, underscoring the importance of age-specific interpretation in paediatric liver ultrasound.

Graphical Abstract