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<p>This scoping review characterizes the relationship of blood brain biomarkers (BBM) to outcomes in pediatric congenital heart disease (CHD) and pediatric cardiac arrest (CA). PubMed, Embase, the Cochrane Library, and Web of Science were searched on 9/25/23 and again on 1/7/26 for literature on pediatric populations with brain injury and CHD and/or CA. Inclusion criteria were: (1) human pediatric subjects ≤ 18&#xa0;years of age who have CHD and/or underwent CA, (2) BBM. Exclusion criteria were: (1) adult populations, (2) studies without BBM, (3) inflammatory or imaging biomarkers. This review is reported following the PRISMA extension for scoping reviews (PRISMA-ScR) and conducted following a study protocol developed in line with the PRISMA-P reporting guidelines. A total of 3687 articles were screened by a minimum of two reviewers; 87 were included in this review. All studies incorporated at least 1 of 13 included BBM with the most frequent being S100B (n = 53, 60.9%), GFAP (n = 27, 31.0%), and NSE (n = 32, 36.8%). 51.7% included neurologic imaging/monitoring (n = 45/87), and 49.4% specified neurodevelopmental/neurofunctional testing within neurologic outcome analysis (n = 43/87). 67.4% of studies reporting neurodevelopmental/functional testing observed a correlation between BBM and poor neurologic outcome (n = 29/43). BBM show promise in predicting neurologic outcomes in pediatric patients following cardiac arrest and in the setting of surgical procedures and other interventions for CHD patients. Due to the limited number of studies, further research is needed.</p>

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Brain Biomarkers in Pediatric Cardiac Disease: A Scoping Review of the Literature from 1998 to 2026

  • 期刊论文

  • 发表日期：

    2026年6月26日

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  • Ryan Luke Sodemann,
  • Amanda Mosher,
  • Emma Hartman,
  • Philip Espinola Coombs,
  • Rebekah Mannix,
  • Elizabeth Pace

摘要

This scoping review characterizes the relationship of blood brain biomarkers (BBM) to outcomes in pediatric congenital heart disease (CHD) and pediatric cardiac arrest (CA). PubMed, Embase, the Cochrane Library, and Web of Science were searched on 9/25/23 and again on 1/7/26 for literature on pediatric populations with brain injury and CHD and/or CA. Inclusion criteria were: (1) human pediatric subjects ≤ 18 years of age who have CHD and/or underwent CA, (2) BBM. Exclusion criteria were: (1) adult populations, (2) studies without BBM, (3) inflammatory or imaging biomarkers. This review is reported following the PRISMA extension for scoping reviews (PRISMA-ScR) and conducted following a study protocol developed in line with the PRISMA-P reporting guidelines. A total of 3687 articles were screened by a minimum of two reviewers; 87 were included in this review. All studies incorporated at least 1 of 13 included BBM with the most frequent being S100B (n = 53, 60.9%), GFAP (n = 27, 31.0%), and NSE (n = 32, 36.8%). 51.7% included neurologic imaging/monitoring (n = 45/87), and 49.4% specified neurodevelopmental/neurofunctional testing within neurologic outcome analysis (n = 43/87). 67.4% of studies reporting neurodevelopmental/functional testing observed a correlation between BBM and poor neurologic outcome (n = 29/43). BBM show promise in predicting neurologic outcomes in pediatric patients following cardiac arrest and in the setting of surgical procedures and other interventions for CHD patients. Due to the limited number of studies, further research is needed.