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<p>The advent of partial heart transplant (PHT) of living valves necessitates robust measures of valve growth. Traditional measurement of aortic valve annular dimension can be confounded by cardiac dilation and does not evaluate the growth of aortic valve leaflets. Measurement of valve leaflet length growth over time has not been studied. We conducted a retrospective cohort study of 12 infants post–orthotopic heart transplant (OHT) and 12 infants with ventricular septal defects (VSDs) with ≥ 5 years of serial echocardiographic data. Leaflet length and annular dimension were measured, and inter-rater reliability assessed. Aortic leaflet length demonstrated good inter-rater reliability and consistent growth over time. Leaflet length is a reliable, feasible, and theoretically dilation-independent measure of semilunar valve growth and may improve longitudinal assessment in patients undergoing PHT.</p>

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Leaflet Length is a Reliable Measure of Aortic Valve Growth

  • 期刊论文

  • 发表日期：

    2026年4月17日

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  • Timothy E. Nissen,
  • Simon Chung,
  • Andrew W. Brown,
  • Emily Sanders,
  • Nirbhay Parashar,
  • Almontasser Bella Kassier,
  • Kenneth R. Knecht,
  • Taufiek Konrad Rajab,
  • Amna Qasim

摘要

The advent of partial heart transplant (PHT) of living valves necessitates robust measures of valve growth. Traditional measurement of aortic valve annular dimension can be confounded by cardiac dilation and does not evaluate the growth of aortic valve leaflets. Measurement of valve leaflet length growth over time has not been studied. We conducted a retrospective cohort study of 12 infants post–orthotopic heart transplant (OHT) and 12 infants with ventricular septal defects (VSDs) with ≥ 5 years of serial echocardiographic data. Leaflet length and annular dimension were measured, and inter-rater reliability assessed. Aortic leaflet length demonstrated good inter-rater reliability and consistent growth over time. Leaflet length is a reliable, feasible, and theoretically dilation-independent measure of semilunar valve growth and may improve longitudinal assessment in patients undergoing PHT.