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<p>The left atrium (LA) may be labeled as a “forgotten” chamber in echocardiographic evaluation of pediatric myocarditis. We recently demonstrated that LA stiffness can identify both diastolic dysfunction and myocardial injury in children with COVID-19. We sought to investigate whether LA stiffness is abnormal in children with acute myocarditis and preserved ejection fraction. We retrospectively analyzed 51 pediatric patients with acute myocarditis diagnosed by cardiac MRI based on updated Lake-Louise-Criteria, along with 40 age-matched healthy controls. Only patients with preserved LVEF (&gt; 55%) were included, given their increased risk of adverse outcomes due to diastolic impairment. Follow-up imaging was available for 41 of the 51 patients. LV systolic and diastolic function, and LA strain were evaluated by conventional 2D and speckle-tracking echocardiography. LA stiffness was calculated as the ratio of E/e’ to peak LA strain as depicted in following equation: <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="246_2025_4078_Article_IEq1.gif" Format="GIF" Height="27" Rendition="HTML" Resolution="72" Type="Linedraw" Width="216" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:LA\:Stiffness=\:\frac{average\:E/e{\prime\:}}{\:peak\:LA\:strain}\:\)</EquationSource> </InlineEquation> (%<sup>−1</sup>). LA stiffness was significantly increased in myocarditis patients (0.27 ± 0.09 vs. 0.15 ± 0.04%<sup>−1</sup>, <i>p</i> &lt; 0.001) and remained elevated at early follow-up. LA stiffness showed the best correlation with peak BNP (<i>r</i> = 0.66, <i>p</i> &lt; 0.001). Moreover, LA stiffness had the highest diagnostic performance among all echocardiographic indices, with an AUC of 0.94, and remained an independent diagnostic power in multivariable regression model (OR 1.58 [95% CI: 1.32–1.89], <i>p</i> &lt; 0.001). When it was incorporated into a composite score with LV peak longitudinal strain, the AUC yielded the highest with 98% sensitivity. An optimal LA stiffness cutoff of 0.20%<sup>−1</sup> may provide incremental value as a new diagnostic marker for the diagnosis of acute myocarditis with preserved LVEF in children, when this value is exceeded.</p>

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Left Atrial Stiffness Identifies Children with Magnetic-Resonance-Imaging-Proven Acute Myocarditis Despite Preserved Left Ventricular Systolic Function

  • 期刊论文

  • 发表日期：

    2025年11月6日

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  • Ryusuke Numata,
  • Renzo Calderon-Anyosa,
  • Danish Vaiyani,
  • Sarina Sun,
  • Yan Wang,
  • Laura Mercer-Rosa,
  • David M. Biko,
  • Anirban Banerjee

摘要

The left atrium (LA) may be labeled as a “forgotten” chamber in echocardiographic evaluation of pediatric myocarditis. We recently demonstrated that LA stiffness can identify both diastolic dysfunction and myocardial injury in children with COVID-19. We sought to investigate whether LA stiffness is abnormal in children with acute myocarditis and preserved ejection fraction. We retrospectively analyzed 51 pediatric patients with acute myocarditis diagnosed by cardiac MRI based on updated Lake-Louise-Criteria, along with 40 age-matched healthy controls. Only patients with preserved LVEF (> 55%) were included, given their increased risk of adverse outcomes due to diastolic impairment. Follow-up imaging was available for 41 of the 51 patients. LV systolic and diastolic function, and LA strain were evaluated by conventional 2D and speckle-tracking echocardiography. LA stiffness was calculated as the ratio of E/e’ to peak LA strain as depicted in following equation: \(\:LA\:Stiffness=\:\frac{average\:E/e{\prime\:}}{\:peak\:LA\:strain}\:\) (%−1). LA stiffness was significantly increased in myocarditis patients (0.27 ± 0.09 vs. 0.15 ± 0.04%−1, p < 0.001) and remained elevated at early follow-up. LA stiffness showed the best correlation with peak BNP (r = 0.66, p < 0.001). Moreover, LA stiffness had the highest diagnostic performance among all echocardiographic indices, with an AUC of 0.94, and remained an independent diagnostic power in multivariable regression model (OR 1.58 [95% CI: 1.32–1.89], p < 0.001). When it was incorporated into a composite score with LV peak longitudinal strain, the AUC yielded the highest with 98% sensitivity. An optimal LA stiffness cutoff of 0.20%−1 may provide incremental value as a new diagnostic marker for the diagnosis of acute myocarditis with preserved LVEF in children, when this value is exceeded.