Anatomical and physiological differences in structural heart lesions may affect peak aerobic capacity (<InlineEquation ID="IEq1"> <EquationSource Format="TEX">$\dot{V}$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </math></EquationSource> </InlineEquation>O2peak) and influence sports participation in children with congenital heart disease (CHD). We hypothesized that a higher frequency of sports participation would be associated with higher <InlineEquation ID="IEq2"> <EquationSource Format="TEX">$\dot{V}{O}_{2peak}$</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> <msub> <mi>O</mi> <mrow> <mn>2</mn> <mi>p</mi> <mi>e</mi> <mi>a</mi> <mi>k</mi> </mrow> </msub> </mrow> </math></EquationSource> </InlineEquation> in these patients. A two-year, single-center, retrospective review (May 2016–November 2018) was conducted in CHD patients who had a maximal cardiopulmonary exercise test (CPET) and documented sport participation. Sports participation was categorized into 3 groups: 0–1 days/week; 2–3 days/week; and ≥ 4 days/week. <InlineEquation ID="IEq3"> <EquationSource Format="TEX">$\dot{V}$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </math></EquationSource> </InlineEquation>O2peak z-scores, %<InlineEquation ID="IEq4"> <EquationSource Format="TEX">$\dot{V}$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </math></EquationSource> </InlineEquation>O2 at gas exchange threshold (<InlineEquation ID="IEq5"> <EquationSource Format="TEX">$\dot{V}{O}_{2GET}$</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> <msub> <mi>O</mi> <mrow> <mn>2</mn> <mi>G</mi> <mi>E</mi> <mi>T</mi> </mrow> </msub> </mrow> </math></EquationSource> </InlineEquation>), and O2 pulse were calculated. Z-scores were calculated based on a reference population. Means and standard deviation (SD) are reported. p < 0.05 was considered statistically significant. In our study cohort (n = 56),<InlineEquation ID="IEq6"> <EquationSource Format="TEX">$\dot{V}$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </math></EquationSource> </InlineEquation>O2peak z-score was − 1.01 ± 0.95; 83% had a z-score within ± 2 SD, while 59% were within one SD. The overall regression for sport participation with <InlineEquation ID="IEq7"> <EquationSource Format="TEX">$\dot{V}{O}_{2peak}$</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> <msub> <mi>O</mi> <mrow> <mn>2</mn> <mi>p</mi> <mi>e</mi> <mi>a</mi> <mi>k</mi> </mrow> </msub> </mrow> </math></EquationSource> </InlineEquation> and <InlineEquation ID="IEq8"> <EquationSource Format="TEX">$\dot{V}{O}_{2GET}$</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> <msub> <mi>O</mi> <mrow> <mn>2</mn> <mi>G</mi> <mi>E</mi> <mi>T</mi> </mrow> </msub> </mrow> </math></EquationSource> </InlineEquation> was statistically significant (R2 = 0.40, F(4, 54) = 11.44, p = < .0001) and (R2 = 0.17, F(4, 54) = 3.46, p = 0.0227), respectively. There was a significant main effect for O2 pulse (R2 = 0.41, F(4, 52) = 11.91, p < 0.0001) but not for HRpeak (p = 0.86), SBPpeak (p = 0.74) or DBPpeak (p = 0.94). <InlineEquation ID="IEq9"> <EquationSource Format="TEX">$\dot{V}$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </math></EquationSource> </InlineEquation>O2peak is higher in those who participate in sports compared to those who do not. It is unclear whether those with a higher <InlineEquation ID="IEq10"> <EquationSource Format="TEX">$\dot{V}$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </math></EquationSource> </InlineEquation>O2peak are more inclined to participate in sports or whether sports participation leads to a higher <InlineEquation ID="IEq11"> <EquationSource Format="TEX">$\dot{V}$</EquationSource> <EquationSource Format="MATHML"><math> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </math></EquationSource> </InlineEquation>O2peak.

Aerobic Fitness is Related to Sports Participation in Children with Congenital Heart Disease

期刊论文
发表日期：

2025年9月25日

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Astrid-Marie De Souza,
Kathryn R Armstrong,
Kimberly Hoskins,
Nicholas Tran,
Kaelan C. Naylor,
Hilary V. Romans,
James E. Potts,
Martin C. Hosking,
David C. Clarke

摘要

Anatomical and physiological differences in structural heart lesions may affect peak aerobic capacity ( $\dot{V}$ $\dot{V}$ O_2peak) and influence sports participation in children with congenital heart disease (CHD). We hypothesized that a higher frequency of sports participation would be associated with higher $\dot{V}{O}_{2peak}$ $\dot{V} O_{2 p e a k}$ in these patients. A two-year, single-center, retrospective review (May 2016–November 2018) was conducted in CHD patients who had a maximal cardiopulmonary exercise test (CPET) and documented sport participation. Sports participation was categorized into 3 groups: 0–1 days/week; 2–3 days/week; and ≥ 4 days/week. $\dot{V}$ $\dot{V}$ O_2peak z-scores, % $\dot{V}$ $\dot{V}$ O₂ at gas exchange threshold ( $\dot{V}{O}_{2GET}$ $\dot{V} O_{2 G E T}$ ), and O₂ pulse were calculated. Z-scores were calculated based on a reference population. Means and standard deviation (SD) are reported. p < 0.05 was considered statistically significant. In our study cohort (n = 56), $\dot{V}$ $\dot{V}$ O_2peak z-score was − 1.01 ± 0.95; 83% had a z-score within ± 2 SD, while 59% were within one SD. The overall regression for sport participation with $\dot{V}{O}_{2peak}$ $\dot{V} O_{2 p e a k}$ and $\dot{V}{O}_{2GET}$ $\dot{V} O_{2 G E T}$ was statistically significant (R² = 0.40, F(4, 54) = 11.44, p = < .0001) and (R² = 0.17, F(4, 54) = 3.46, p = 0.0227), respectively. There was a significant main effect for O₂ pulse (R² = 0.41, F(4, 52) = 11.91, p < 0.0001) but not for HR_peak (p = 0.86), SBP_peak (p = 0.74) or DBP_peak (p = 0.94). $\dot{V}$ $\dot{V}$ O_2peak is higher in those who participate in sports compared to those who do not. It is unclear whether those with a higher $\dot{V}$ $\dot{V}$ O_2peak are more inclined to participate in sports or whether sports participation leads to a higher $\dot{V}$ $\dot{V}$ O_2peak.