Reinforcement learning for multi-agent games has attracted lots of attention recently. However, given the challenge of solving Nash equilibria, existing works with guaranteed polynomial complexities either focus on variants of zero-sum and potential games, or aim at solving (coarse) correlated equilibria, or require access to simulators, or rely on certain assumptions that are hard to verify. This work proposes MF-OML (Mean-Field Occupation-Measure Learning), an online mean-field reinforcement learning algorithm for computing approximate Nash equilibria of large population sequential symmetric games. MF-OML is the first fully polynomial multi-agent reinforcement learning algorithm for provably solving Nash equilibria (up to mean-field approximation gaps that vanish as the number of players N goes to infinity) beyond variants of zero-sum and potential games. When evaluated by the cumulative deviation from Nash equilibria, the algorithm is shown to achieve a high probability regret bound of \(\tilde{O}(M^{3/4}+N^{-1/2}M)\) for games with the strong Lasry-Lions monotonicity condition, and a regret bound of \(\tilde{O}(M^{11/12}+N^{-1/6}M)\) for games with only the Lasry-Lions monotonicity condition, where M is the total number of episodes and N is the number of agents of the game. As a by-product, we also obtain the first tractable globally convergent computational algorithm for computing approximate Nash equilibria of monotone mean-field games.