Background <p>War-related injuries are characterized by high-energy trauma and a high incidence of infection. Although plastic surgeons are fundamental in reconstructing these defects, specific literature regarding the incidence of infections in war-wounded patients treated by this specialty is scarce. We aim to evaluate the presence of infection and associated factors in patients wounded in the Russo-Ukrainian conflict and treated by the Plastic Surgery Department at the General Defense Hospital.</p> Methods <p>We included patients treated between May 2022 and June 2025 who required plastic surgery intervention for subacute injuries; patients transferred solely for rehabilitation were excluded. Epidemiological data, injury characteristics, the presence of infection, and detected microorganisms were recorded.</p> Results <p>Fifteen patients met the inclusion criteria. Associated bone lesions were present in 86.6% of cases. Active infection was detected in 7 patients (46.6%): four diagnoses prior to surgery and three postoperative complications. Infection control was achieved in 5 cases, although one case required amputation.</p> Conclusions <p>The presence of bone lesions and soft tissue coverage defects correlates with a higher infectious risk, which is consistent with the profile of patients requiring plastic surgery. Plastic surgeons managing these injuries must anticipate infection, perform aggressive debridement prior to reconstruction, utilize large flaps, and work within a multidisciplinary environment. Level of Evidence: Level IV, risk / prognostic study.</p>