Scholarlink

Background <p>While early excision and grafting are cornerstones of burn management, achieving rapid and complication-free healing of the skin graft donor site remains a critical challenge in reducing patient morbidity. This clinical trial aimed to compare donor site healing outcomes in patients with deep second- and third-degree burns treated using three therapeutic approaches: subcutaneous insulin injection, amniotic membrane dressing, and simple Vaseline gauze dressing.</p> Methods <p>This randomized clinical trial was conducted on 80 patients (50 males, 30 females; mean age 50.92 ± 21.31 years) with deep second- and third-degree burns involving 20–40% of total body surface area (TBSA), admitted to the Burn and Trauma Hospital in Ahvaz, Iran. A within-subject design was employed, in which each patient’s donor site was divided to receive all three interventions, allowing direct comparison under identical systemic and anatomical conditions. Donor site healing was quantitatively assessed using the Donor Site Healing Score (DSHS).</p> Results <p>Statistical analysis demonstrated significant differences in donor site healing scores among the three treatment modalities at different time points (<i>P</i> &lt; 0.005). On postoperative day 5, the simple Vaseline gauze dressing showed higher healing scores (<i>P</i> &lt; 0.001). By day 14, donor sites treated with amniotic membrane and subcutaneous insulin exhibited significantly improved healing compared with simple dressing (<i>P</i> &lt; 0.001). At day 30, healing outcomes were comparable among the three groups, with no statistically significant differences observed (<i>P</i> = 0.75).</p> Conclusions <p>The findings indicate that amniotic membrane dressing and subcutaneous insulin injection are associated with accelerated early and intermediate donor site healing compared with simple Vaseline gauze. Given their comparable efficacy, amniotic membrane dressing may be preferred in clinical practice due to its cost-effectiveness and lower risk of complications. The within-subject design of this study provides robust comparative evidence to support flexible, evidence-based donor site management in burn surgery. Level I, therapeutic study.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative evaluation of donor site healing in second- and third-degree burns using subcutaneous insulin injection, amniotic membrane, and simple vaseline gauze dressing: a clinical trial

  • 期刊论文

  • 发表日期：

    2026年2月9日

查看全文
  • Mahtab Farhadi,
  • Ali Alizadeh,
  • Nasrin Khodadadi,
  • Abdulreza Sheikhi,
  • Roozbeh Rahbar,
  • Seyed Bahman Ghaderian,
  • Pegah Alsadat Fatemi

摘要

Background

While early excision and grafting are cornerstones of burn management, achieving rapid and complication-free healing of the skin graft donor site remains a critical challenge in reducing patient morbidity. This clinical trial aimed to compare donor site healing outcomes in patients with deep second- and third-degree burns treated using three therapeutic approaches: subcutaneous insulin injection, amniotic membrane dressing, and simple Vaseline gauze dressing.

Methods

This randomized clinical trial was conducted on 80 patients (50 males, 30 females; mean age 50.92 ± 21.31 years) with deep second- and third-degree burns involving 20–40% of total body surface area (TBSA), admitted to the Burn and Trauma Hospital in Ahvaz, Iran. A within-subject design was employed, in which each patient’s donor site was divided to receive all three interventions, allowing direct comparison under identical systemic and anatomical conditions. Donor site healing was quantitatively assessed using the Donor Site Healing Score (DSHS).

Results

Statistical analysis demonstrated significant differences in donor site healing scores among the three treatment modalities at different time points (P < 0.005). On postoperative day 5, the simple Vaseline gauze dressing showed higher healing scores (P < 0.001). By day 14, donor sites treated with amniotic membrane and subcutaneous insulin exhibited significantly improved healing compared with simple dressing (P < 0.001). At day 30, healing outcomes were comparable among the three groups, with no statistically significant differences observed (P = 0.75).

Conclusions

The findings indicate that amniotic membrane dressing and subcutaneous insulin injection are associated with accelerated early and intermediate donor site healing compared with simple Vaseline gauze. Given their comparable efficacy, amniotic membrane dressing may be preferred in clinical practice due to its cost-effectiveness and lower risk of complications. The within-subject design of this study provides robust comparative evidence to support flexible, evidence-based donor site management in burn surgery. Level I, therapeutic study.