Background <p>Skin grafting is a fundamental tool in the armamentarium of the reconstructive plastic surgeon and is one of the most common reconstructive procedures. One of the key factors for a successful skin graft take, is its stable fixation to the wound bed, which is essential for ensuring rapid integration. Several popular fixation methods are available today, each with its own set of advantages and disadvantages. These include absorbable and non-absorbable materials. This literature review aims to summarize the current body of evidence concerning absorbable skin staples, for skin graft fixation, in the field of plastic surgery. Our hypothesis is that the available data adequately supports the use of this technology.</p> Methods <p> A literature review via PubMed and Google Scholar was conducted to identify publications that used the phrases, “absorbable”, “staples”,” skin graft” and “surgery”, following the PRISMA guidelines.</p> Results <p>The search results yielded 596 papers, after duplications subtraction. Following reduction process as per exclusion criteria, the authors identified and fully reviewed fifty-four articles. Of these, six full-text articles were eligible for qualitative synthesis.</p> Conclusions <p>Sufficient data has accumulated to support the selective use of absorbable skin staples for split-thickness skin graft fixation. Particularly in geriatric and pediatric age groups and in anatomically complex reconstructive surgeries. Level of Evidence: Not ratable</p>