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Background <p>Rhinoplasty is a complex surgery performed to reshape and improve nasal function using open or closed techniques. In recent years, platelet-rich plasma (PRP) has demonstrated high potential in improving outcomes post-rhinoplasty surgery.</p> Methods <p>From inception to September 2024, PubMed, MEDLINE, Cochrane Library, Google Scholar, and Web of Science were used to conduct a comprehensive literature search for peer-reviewed original research articles. The risk of bias in the included randomized controlled studies was assessed using the risk of bias visualization tool developed by the Cochrane Collaboration. The Newcastle–Ottawa Scale was used to determine the risk of bias in observational studies. Data were then systematically extracted and analyzed.</p> Results <p>The search yielded 307 records, of which 14 studies meeting the eligibility criteria were included. The analysis showed that PRP improved wound healing, decreased pain, and minimized postoperative complications. Meta-analyses showed significant reductions in nasal crust formation (p = 0.003, SMD = -0.69, 95% CI (-1.14, -0.24)) and statistically insignificant postoperative pain levels (p = 0.31, Standardized Mean Difference (SMD) = -3.90, SMD = 95% CI (-11.36, 3.57)). Moreover, applying PRP improved patient satisfaction and Sino-Nasal Outcome Test (SNOT)-25 scores. It also exhibited enhanced long-term outcomes, including successful septal perforation repair and reduced graft resorption.</p> Conclusions <p>PRP proved effective in rhinoplasty, significantly improving healing outcomes with minimal complications and satisfaction in patients. Nevertheless, it is essential to consider individual patient factors, surgical objectives, and nasal conditions involved.</p> <p>Level of Evidence: Level I, therapeutic study.</p>

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Efficacy of platelet-rich plasma in enhancing postoperative outcomes in rhinoplasty: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年3月8日

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  • Abdulrahman G. Alosaimi,
  • Mohammed A. Alhejaily,
  • Ibrahim Abbas Tawfiq,
  • Mohammed. Salman Almutairi,
  • Walaa Ali Nawawi Felemban,
  • Mohammed Asad Albouq,
  • Adel Banjar

摘要

Background

Rhinoplasty is a complex surgery performed to reshape and improve nasal function using open or closed techniques. In recent years, platelet-rich plasma (PRP) has demonstrated high potential in improving outcomes post-rhinoplasty surgery.

Methods

From inception to September 2024, PubMed, MEDLINE, Cochrane Library, Google Scholar, and Web of Science were used to conduct a comprehensive literature search for peer-reviewed original research articles. The risk of bias in the included randomized controlled studies was assessed using the risk of bias visualization tool developed by the Cochrane Collaboration. The Newcastle–Ottawa Scale was used to determine the risk of bias in observational studies. Data were then systematically extracted and analyzed.

Results

The search yielded 307 records, of which 14 studies meeting the eligibility criteria were included. The analysis showed that PRP improved wound healing, decreased pain, and minimized postoperative complications. Meta-analyses showed significant reductions in nasal crust formation (p = 0.003, SMD = -0.69, 95% CI (-1.14, -0.24)) and statistically insignificant postoperative pain levels (p = 0.31, Standardized Mean Difference (SMD) = -3.90, SMD = 95% CI (-11.36, 3.57)). Moreover, applying PRP improved patient satisfaction and Sino-Nasal Outcome Test (SNOT)-25 scores. It also exhibited enhanced long-term outcomes, including successful septal perforation repair and reduced graft resorption.

Conclusions

PRP proved effective in rhinoplasty, significantly improving healing outcomes with minimal complications and satisfaction in patients. Nevertheless, it is essential to consider individual patient factors, surgical objectives, and nasal conditions involved.

Level of Evidence: Level I, therapeutic study.