Purpose <p>To conduct an exploratory analysis of quantitative and semi-quantitative perfusion-weighted MRI (PWI) parameters across various intraocular lesions and assess their relationship with fluorescein angiography (FAG) features.</p> Methods <p>Thirty-eight patients with twelve different diagnoses who underwent 3T dynamic contrast-enhanced MRI (DCE-MRI) of the eye were included, with diagnosis confirmed either by histopathology or clinical course of the disease. Tofts pharmacokinetic modelling was used to calculate K^trans, v_e, and k_ep values. Semi-quantitative relative peak intensity and outflow percentage were derived from time-intensity curves and compared with quantitative parameters. FAG images were evaluated for blocking effects, pinpoint and diffuse leakages.</p> Results <p>Median values of quantitative and semi-quantitative parameters varied across lesion types. Haemangiomas showed the highest K^trans (median = 6.35&#xa0;min^− 1) and k_ep (median = 3.8&#xa0;min^− 1). Uveal melanomas showed high K^trans (median = 0.68&#xa0;min^− 1) and k_ep (median = 2.45&#xa0;min^− 1) in comparison with choroidal naevi and metastases. Quantitative and semi-quantitative parameters showed significant correlation across all intensity groups (all R² &gt; 0.36, all <i>p</i> &lt; 0.04). The correlation between K^trans and relative peak intensity differed for hypo- and isointense lesions versus hyperintense lesions (both <i>p</i> &lt; 0.002). Statistical comparison between individual diagnoses was not possible due to limited sample size per diagnosis. Quantitative PWI parameters showed correspondence with FAG features.</p> Conclusion <p>This study provided quantitative and semi-quantitative PWI parameters for various intraocular lesions. Semi-quantitative PWI parameters may provide comparable information on lesion vascularity when stratified by T1 signal intensity.</p>