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Purpose <p>To assess the uptake patterns of adult-type non-enhanced gliomas in the pre-angiogenic phase on [<sup>11</sup>C] methionine (MET) PET.</p> Methods <p>We included 52 astrocytoma (Group A), 34 oligodendroglioma (Group O), and 21 glioblastoma (Group G) cases. Regions of interest (ROIs) were defined based on T2-weighted images of high-intensity lesions encompassing tumor volume. The maximum tumor-to-brain ratios (TBR<sub>max</sub>) were calculated from PET data. ROIs were internally layered at 5-mm intervals from the tumor surface to assess MET uptake distribution. Moderate (TBR<sub>max</sub> ≥1.3) and high (TBR<sub>max</sub> ≥2.0) uptakes were classified into three patterns based on the extent and distribution.</p> Results <p>TBR<sub>max</sub> was significantly lower in Group A than in Groups O and G. TBR<sub>max</sub> was more frequently observed in the outermost 0–5&#xa0;mm layer in all groups. Seventy-three cases with TBR<sub>max</sub> ≥1.3 exhibited the whole pattern in 13 (17.8%) and partial or spot patterns in 60 (82.2%) cases; partial or spot pattern cases were most frequently identified as surface/outside patterns (60.3%). Twenty-seven cases with TBR<sub>max</sub> ≥2.0 exhibited the whole pattern in 5 (18.5%) and partial or spot patterns in 22 (81.5%) cases; partial or spot pattern cases were identified as central or surface/outside patterns, and none of the cases showed surface/inside patterns, indicating a high-uptake area in the deeper part of the brain.</p> Conclusion <p>In non-enhanced gliomas, MET accumulation was concentrated at the periphery of the tumor. Although some cases showed MET uptake throughout the tumor, none showed focal high uptake deep in the brain.</p>

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Uptake patterns of Adult-type Non-Enhanced diffuse gliomas on [11C] methionine positron emission tomography

  • 期刊论文

  • 发表日期：

    2025年9月22日

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  • Shoji Yasuda,
  • Naoya Imai,
  • Hirohito Yano,
  • Yuka Ikegame,
  • Soko Ikuta,
  • Takashi Maruyama,
  • Noriyuki Nakayama,
  • Morio Kumagai,
  • Yoshihiro Muragaki,
  • Jun Shinoda,
  • Tsuyoshi Izumo

摘要

Purpose

To assess the uptake patterns of adult-type non-enhanced gliomas in the pre-angiogenic phase on [11C] methionine (MET) PET.

Methods

We included 52 astrocytoma (Group A), 34 oligodendroglioma (Group O), and 21 glioblastoma (Group G) cases. Regions of interest (ROIs) were defined based on T2-weighted images of high-intensity lesions encompassing tumor volume. The maximum tumor-to-brain ratios (TBRmax) were calculated from PET data. ROIs were internally layered at 5-mm intervals from the tumor surface to assess MET uptake distribution. Moderate (TBRmax ≥1.3) and high (TBRmax ≥2.0) uptakes were classified into three patterns based on the extent and distribution.

Results

TBRmax was significantly lower in Group A than in Groups O and G. TBRmax was more frequently observed in the outermost 0–5 mm layer in all groups. Seventy-three cases with TBRmax ≥1.3 exhibited the whole pattern in 13 (17.8%) and partial or spot patterns in 60 (82.2%) cases; partial or spot pattern cases were most frequently identified as surface/outside patterns (60.3%). Twenty-seven cases with TBRmax ≥2.0 exhibited the whole pattern in 5 (18.5%) and partial or spot patterns in 22 (81.5%) cases; partial or spot pattern cases were identified as central or surface/outside patterns, and none of the cases showed surface/inside patterns, indicating a high-uptake area in the deeper part of the brain.

Conclusion

In non-enhanced gliomas, MET accumulation was concentrated at the periphery of the tumor. Although some cases showed MET uptake throughout the tumor, none showed focal high uptake deep in the brain.