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Purpose <p>Metronidazole is a widely used antimicrobial and is generally well-tolerated, but its adverse effects can rarely manifest as ataxia, dysarthria, and encephalopathy. Rarely it can cause severe neurological toxicity in the form of Metronidazole-Induced Encephalopathy.</p> Methods <p>We report a 48-year-old female with acute cerebellar symptoms and altered sensorium following a 12-day course of Metronidazole.</p> Results <p>Magnetic Resonance Imaging (MRI) revealed unusual diffuse leukoencephalopathy involving the cerebellar, brainstem, and cerebral white matter with rapid clinical and radiological resolution occurred after discontinuation.</p> Conclusions <p>This case highlights the importance of early recognition of symptoms and immediate discontinuation of Metronidazole to prevent irreversible neurological sequelae, even in cases with limited exposure.</p>

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A rare presentation of acute onset metronidazole-induced leukoencephalopathy with rapid resolution: a case report

  • 期刊论文

  • 发表日期：

    2025年2月19日

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  • Govind Singh Mann,
  • Neeti Ajay Gupta,
  • Nitin Jain

摘要

Purpose

Metronidazole is a widely used antimicrobial and is generally well-tolerated, but its adverse effects can rarely manifest as ataxia, dysarthria, and encephalopathy. Rarely it can cause severe neurological toxicity in the form of Metronidazole-Induced Encephalopathy.

Methods

We report a 48-year-old female with acute cerebellar symptoms and altered sensorium following a 12-day course of Metronidazole.

Results

Magnetic Resonance Imaging (MRI) revealed unusual diffuse leukoencephalopathy involving the cerebellar, brainstem, and cerebral white matter with rapid clinical and radiological resolution occurred after discontinuation.

Conclusions

This case highlights the importance of early recognition of symptoms and immediate discontinuation of Metronidazole to prevent irreversible neurological sequelae, even in cases with limited exposure.