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<p>Pharmacokinetic drug-drug interactions (DDIs) can compromise the efficacy or safety of oral antithrombotic therapies (defined as oral anticoagulants or antiplatelet agents) due to under- or overexposure. Currently, there is limited published data on DDIs involving direct oral anticoagulants, and there is an alarming lack of clear data on DDIs involving antiplatelet agents. In this paper, we elaborated a comprehensive, up-to-date pocket guide on pharmacokinetic DDIs showing five possible levels of DDI (major, moderate or weak increase and major or moderate/weak decrease in antithrombotic drug exposure). The aim of this tool is to help prescribers, in particular cardiologists, to safely prescribe new antithrombotic therapies based on an individualised assessment of bleeding and thrombotic risk.</p>

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Thrombocheck: a practical pocket guide to pharmacokinetic drug-drug interactions in oral antithrombotic therapy

  • 期刊论文

  • 发表日期：

    2025年12月22日

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  • Alma Feka,
  • Maxime G. Zermatten,
  • Sarah Hugelshofer,
  • Mario Verdugo-Marchese,
  • Stéphane Fournier,
  • Lorenzo Alberio,
  • Zied Ltaief,
  • Nancy Perrottet

摘要

Pharmacokinetic drug-drug interactions (DDIs) can compromise the efficacy or safety of oral antithrombotic therapies (defined as oral anticoagulants or antiplatelet agents) due to under- or overexposure. Currently, there is limited published data on DDIs involving direct oral anticoagulants, and there is an alarming lack of clear data on DDIs involving antiplatelet agents. In this paper, we elaborated a comprehensive, up-to-date pocket guide on pharmacokinetic DDIs showing five possible levels of DDI (major, moderate or weak increase and major or moderate/weak decrease in antithrombotic drug exposure). The aim of this tool is to help prescribers, in particular cardiologists, to safely prescribe new antithrombotic therapies based on an individualised assessment of bleeding and thrombotic risk.