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<p>Exposure to low energy availability (LEA) can stimulate metabolic adaptations that have been shown to disrupt bone remodeling as suggested by suppressed markers of bone formation and/or increased markers of bone resorption. Previous studies suggest that brief, high-impact exercise during short-term energy restriction may stimulate an osteogenic response and mitigate the negative effect of LEA on bone health. This randomized, crossover study of twelve recreational female runners (age: 26.4 ± 3.9&#xa0;years, VO<sub>2max</sub>: 45.3 ± 7.2&#xa0;mL/kg/min) assessed the short-term effects of jumping exercises on markers of bone formation and resorption after five days of experimentally-controlled LEA (15&#xa0;kcal/kgFFM/d). Participants completed two LEA conditions that involved daily treadmill running with either no additional exercise (RUN) or an additional 50 jump exercises per day (RUN + J). Fasted bone markers and hormone concentrations were measured on the mornings immediately before and after each intervention period. Bone resorption marker β-CTX was increased over time in both LEA conditions (main effect of time: <i>P</i> = 0.005; preRUN: 0.32 ± 0.21, postRUN: 0.36 ± 0.15&#xa0;ng/mL; preRUN + J: 0.38 ± 0.21, postRUN + J: 0.42 ± 0.19&#xa0;ng/mL) with no interaction effect (<i>P</i> = 0.716). Bone formation biomarkers, PINP and sclerostin, did not change over time (<i>P</i> = 0.517, <i>P</i> = 0.091) or between conditions (<i>P</i> = 0.187, <i>P</i> = 0.666). In conclusion, performing 50 jumping exercises during short-term LEA did not have an effect on markers of bone resorption or formation during short-term LEA induced by running exercise and dietary energy restriction.</p>

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Effects of High-Impact Exercise on Bone Marker Concentrations During Controlled Low Energy Availability in Recreational Female Runners

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月25日

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  • Trisha Sterringer,
  • Craig Sale,
  • Anna Morozov,
  • Jiarui Liang,
  • D. Enette Larson-Meyer

摘要

Exposure to low energy availability (LEA) can stimulate metabolic adaptations that have been shown to disrupt bone remodeling as suggested by suppressed markers of bone formation and/or increased markers of bone resorption. Previous studies suggest that brief, high-impact exercise during short-term energy restriction may stimulate an osteogenic response and mitigate the negative effect of LEA on bone health. This randomized, crossover study of twelve recreational female runners (age: 26.4 ± 3.9 years, VO2max: 45.3 ± 7.2 mL/kg/min) assessed the short-term effects of jumping exercises on markers of bone formation and resorption after five days of experimentally-controlled LEA (15 kcal/kgFFM/d). Participants completed two LEA conditions that involved daily treadmill running with either no additional exercise (RUN) or an additional 50 jump exercises per day (RUN + J). Fasted bone markers and hormone concentrations were measured on the mornings immediately before and after each intervention period. Bone resorption marker β-CTX was increased over time in both LEA conditions (main effect of time: P = 0.005; preRUN: 0.32 ± 0.21, postRUN: 0.36 ± 0.15 ng/mL; preRUN + J: 0.38 ± 0.21, postRUN + J: 0.42 ± 0.19 ng/mL) with no interaction effect (P = 0.716). Bone formation biomarkers, PINP and sclerostin, did not change over time (P = 0.517, P = 0.091) or between conditions (P = 0.187, P = 0.666). In conclusion, performing 50 jumping exercises during short-term LEA did not have an effect on markers of bone resorption or formation during short-term LEA induced by running exercise and dietary energy restriction.