Scholarlink

<p>To investigate the hemodynamic responses and functional connectivity patterns in the visual cortex of patients with acquired brain injury-related esotropia (ABI-ESO) following Binasal Occlusion (BNO) using functional near-infrared spectroscopy (fNIRS). Patients who were diagnosed with ABI-ESO as the ABI-ESO group, and healthy controls were enrolled as the control group. fNIRS was used to monitor cerebral oxyhemoglobin (HbO) concentrations during a visual stimulation task (black-and-white checkerboard) before and after BNO. Changes in activation levels and functional connectivity among visual-related regions were analyzed. Baseline analysis revealed that the ABI-ESO group had significantly lower Occipital Eye Field (OEF) activation and weaker functional connectivity compared to controls. Following BNO, we observed distinct cortical changes. Specifically, the ABI-ESO group exhibited increased activation in the left Parietal Eye Field (<sub>L</sub>PEF). In terms of functional connectivity, coupling strength decreased in the inter-hemispheric pathways between bilateral Frontal (<sub>L</sub>FEF–<sub>R</sub>FEF) and Parietal (<sub>L</sub>PEF–<sub>R</sub>PEF) Eye Fields post-intervention in the ABI-ESO group, suggesting a reorganization of the visual network. ABI-ESO is characterized by baseline cortical hypo-activity and network disruption. BNO therapy facilitates dorsal stream activity and modulates inter-hemispheric connectivity by suppressing maladaptive synchronization. These findings suggest that BNO functions as a neuro-modulatory intervention, offering a preliminary objective rationale for neuro-visual rehabilitation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Binasal occlusion modulates cortical functional connectivity and hemodynamics in acquired paralytic esotropia: a fNIRS study

  • 期刊论文

  • 发表日期：

    2026年3月16日

查看全文
  • Jie Zhou,
  • Ran Du,
  • Xue Wang,
  • Jun Wu,
  • Fubiao Huang,
  • Rui Fang,
  • Yixiong Liang,
  • Ning Song,
  • Wenbin Wei

摘要

To investigate the hemodynamic responses and functional connectivity patterns in the visual cortex of patients with acquired brain injury-related esotropia (ABI-ESO) following Binasal Occlusion (BNO) using functional near-infrared spectroscopy (fNIRS). Patients who were diagnosed with ABI-ESO as the ABI-ESO group, and healthy controls were enrolled as the control group. fNIRS was used to monitor cerebral oxyhemoglobin (HbO) concentrations during a visual stimulation task (black-and-white checkerboard) before and after BNO. Changes in activation levels and functional connectivity among visual-related regions were analyzed. Baseline analysis revealed that the ABI-ESO group had significantly lower Occipital Eye Field (OEF) activation and weaker functional connectivity compared to controls. Following BNO, we observed distinct cortical changes. Specifically, the ABI-ESO group exhibited increased activation in the left Parietal Eye Field (LPEF). In terms of functional connectivity, coupling strength decreased in the inter-hemispheric pathways between bilateral Frontal (LFEF–RFEF) and Parietal (LPEF–RPEF) Eye Fields post-intervention in the ABI-ESO group, suggesting a reorganization of the visual network. ABI-ESO is characterized by baseline cortical hypo-activity and network disruption. BNO therapy facilitates dorsal stream activity and modulates inter-hemispheric connectivity by suppressing maladaptive synchronization. These findings suggest that BNO functions as a neuro-modulatory intervention, offering a preliminary objective rationale for neuro-visual rehabilitation.