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<p>Recently, the application of biodegradable and bioactive packaging as a replacement for petroleum-based packaging has become a trend. The present research aims to investigate the effect of chitosan charge on its characteristics and bioactivities. Findings showed that the chitosan-based film (CHT-film) forming solutions with lower pH possess higher zeta potential (+ 73 mV), conductivity (5.43 mS/cm), and specific viscosity (12.49) values. Moreover, the CHT-film prepared from a solution with pH = 2 presents greater hydrophobicity (<i>θ</i><sub>w</sub> = 98.73; ΔG<i>iwi</i> = -86.42), tensile strength (TS = 6.27&#xa0;MPa), as well as significant antibacterial and antiadhesion activities against <i>Enterococcus hirae</i>, <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, and <i>Pseudomonas aeruginosa</i>. Nevertheless, the variation of the pH parameter did not affect the thickness, opacity, and elongation at break (EB), where all CHT-films were thin (thickness ≈ 18&#xa0;μm), transparent (opacity ≈ 1.5), and presented a good stretching ability (EB ≈ 150%). On the other side, the implication of the positively charged amino group in the mitigation of bacterial adherence was verified by molecular docking. These encouraging results revealed that the CHT-film properties and biological activities can be improved by varying the pH of the CHT-film forming solutions instead of using complementary additives that may negatively affect consumer health or product quality.</p>

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Impact of charge density on the properties and bioactivities of chitosan-based films

  • 期刊论文

  • 发表日期：

    2025年12月26日

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  • Anouar Mouhoub,
  • Amine Guendouz,
  • Zainab El Alaoui-Talibi,
  • Saad Ibnsouda Koraichi,
  • Safae Er Raouan,
  • Cherkaoui El Modafar

摘要

Recently, the application of biodegradable and bioactive packaging as a replacement for petroleum-based packaging has become a trend. The present research aims to investigate the effect of chitosan charge on its characteristics and bioactivities. Findings showed that the chitosan-based film (CHT-film) forming solutions with lower pH possess higher zeta potential (+ 73 mV), conductivity (5.43 mS/cm), and specific viscosity (12.49) values. Moreover, the CHT-film prepared from a solution with pH = 2 presents greater hydrophobicity (θw = 98.73; ΔGiwi = -86.42), tensile strength (TS = 6.27 MPa), as well as significant antibacterial and antiadhesion activities against Enterococcus hirae, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Nevertheless, the variation of the pH parameter did not affect the thickness, opacity, and elongation at break (EB), where all CHT-films were thin (thickness ≈ 18 μm), transparent (opacity ≈ 1.5), and presented a good stretching ability (EB ≈ 150%). On the other side, the implication of the positively charged amino group in the mitigation of bacterial adherence was verified by molecular docking. These encouraging results revealed that the CHT-film properties and biological activities can be improved by varying the pH of the CHT-film forming solutions instead of using complementary additives that may negatively affect consumer health or product quality.