Antioxidant properties of propolis: the systematic and bibliometric analyses of research trends in the last decade (2015–2024)
摘要
Propolis, a resinous substance produced by bees, has garnered significant scientific interest due to its diverse biological activities, particularly its antioxidant properties. This research addresses a notable gap in the literature by providing a comprehensive overview of research trends related to the antioxidant activity of propolis, analyzing 321 articles published in 142 journals between 2015 and 2024. The study reveals a substantial and growing body of research in this area, with a notable increase in publications over the past decade. While Apis mellifera propolis remains the most frequently studied type, there is a growing interest in propolis from stingless bees. The analysis highlights the predominance of studies focusing on Brazilian, Chinese, and Turkish propolis, reflecting regional research interests and propolis availability. A wide range of methodologies are employed, with spectroscopy, chromatography, and in vitro antioxidant assays being the most prevalent. Ethanol is the most used extraction solvent, although alternative methods are being explored. Keyword analysis and thematic mapping reveal a strong emphasis on chemical characterization, particularly the identification and quantification of phenolic compounds, and their relationship to antioxidant capacity. Research priorities have clearly evolved over the past decade. Studies are now moving beyond basic characterization to focus on optimizing extraction methods and exploring novel applications. The study identifies key research gaps, including the necessity of harmonization of methodologies, more comprehensive investigations of stingless bee propolis, and increased focus on in vivo and clinical studies to translate in vitro findings into practical applications. This analysis provides valuable data for researchers, highlighting key areas for future investigation and promoting a more focused and impactful approach to propolis research.