<p>Chia seeds are a valuable component of functional foods due to their rich content of bioactive compounds such as phenolics, omega-3 fatty acids, proteins, dietary fiber, and essential minerals. Their rich phytochemical profile offers several health benefits, including antidiabetic, cardioprotective, anti-inflammatory, and antioxidant effects. This review offers an in-depth review of the phytochemical composition of chia seeds, their medicinal applications, and their roles in food science and technology. Particular emphasis is placed on their use in natural food preservatives, functional foods, and the development of applications such as bioplastics and edible films. Despite their potential, research is required to address challenges associated with sustainability, consistency, and bioavailability. The review also outlines future research priorities for sustainable food development and optimization of chia-derived phytochemicals optimization.</p> Graphical abstract <p></p>