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<p>Alginate microcapsules may be an excellent carrier of therapeutic agents with activity targeting colon cancer cells (CRC). Therefore, in this study, microcapsules based on alginate (Alg), κ-carrageenan (kC) and chitosan (CS) were developed as carriers of the anthocyanin fraction of blueberry (A). The obtained microcapsules were tested for cytotoxic, antiproliferative, antimigratory and antiinvasive activity against CRC cells and biocompatibility with normal colon cells. The profile of bound anthocyanins, their content after 3 months of storage and the degree of swelling in individual sections of the gastrointestinal tract were also assessed. It was found that the highest encapsulation efficiency (76.9%) as well as cytotoxic activity against CRC cells were characterized by Alg/kC/CS/A microcapsules. These microcapsules also showed the lowest effect on cytotoxicity towards normal colon cells. Furthermore, coating the microcapsules with a CS layer significantly improved their swelling profile under simulated intestinal conditions and had a positive effect on the stabilization of anthocyanins during storage. Our results indicate that Alg/kC/CS/A microcapsules can be effectively used to stabilize anthocyanins and deliver them to the colon region.</p>

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Cytotoxic activity of microcapsules with anthocyanin fraction of blueberry fruit against colon cancer cells

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月25日

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  • Natalia Żurek,
  • Ireneusz Kapusta

摘要

Alginate microcapsules may be an excellent carrier of therapeutic agents with activity targeting colon cancer cells (CRC). Therefore, in this study, microcapsules based on alginate (Alg), κ-carrageenan (kC) and chitosan (CS) were developed as carriers of the anthocyanin fraction of blueberry (A). The obtained microcapsules were tested for cytotoxic, antiproliferative, antimigratory and antiinvasive activity against CRC cells and biocompatibility with normal colon cells. The profile of bound anthocyanins, their content after 3 months of storage and the degree of swelling in individual sections of the gastrointestinal tract were also assessed. It was found that the highest encapsulation efficiency (76.9%) as well as cytotoxic activity against CRC cells were characterized by Alg/kC/CS/A microcapsules. These microcapsules also showed the lowest effect on cytotoxicity towards normal colon cells. Furthermore, coating the microcapsules with a CS layer significantly improved their swelling profile under simulated intestinal conditions and had a positive effect on the stabilization of anthocyanins during storage. Our results indicate that Alg/kC/CS/A microcapsules can be effectively used to stabilize anthocyanins and deliver them to the colon region.