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<p>In the&#xa0;food field, HSO<sub>3</sub><sup>-</sup> is commonly used as a beverage additive, antioxidant, enzyme inhibitor, and preservative to extend shelf life and freshness. However, excessive intake of exogenous HSO<sub>3</sub><sup>-</sup> can lead to abnormal HSO<sub>3</sub><sup>-</sup> concentration levels in the body, causing cardiovascular and respiratory diseases. This highlights the urgent need to develop a rapid and sensitive probe for the quantitative detection of HSO<sub>3</sub><sup>-</sup> in foods and biosystems. In this study, we design and synthesize a novel HSO<sub>3</sub><sup>-</sup> fluorescent probe named <b>DCPD</b>. Bioimaging experiments show that <b>DCPD</b> has good mitochondrial targeting and can be used to imaging the redox process of HSO<sub>3</sub><sup>-</sup>/H<sub>2</sub>O<sub>2</sub> in cells and tissue. In addition, <b>DCPD</b> has been used in detecting HSO<sub>3</sub><sup>-</sup> in foods with satisfactory recoveries (98.62–105.06%), further demonstrating its compatibility and utility. Thus, the <b>DCPD</b> probe&#xa0;offers substantial promise for application in food analysis and the assessment of HSO<sub>3</sub><sup>-</sup> concentrations in biological systems.</p> Graphical Abstract <p></p>

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A dual-functional fluorescent probe for biosystem imaging and food safety monitoring of HSO3- with high selectivity and sensitivity

  • 期刊论文

  • 发表日期：

    2025年3月22日

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  • Yumeng Li,
  • Ran Chen,
  • Juanjuan Lv,
  • Jiali Su,
  • Mengxu Gao,
  • Kaifu Ma,
  • Xiupei Cheng,
  • Wei Shu

摘要

In the food field, HSO3- is commonly used as a beverage additive, antioxidant, enzyme inhibitor, and preservative to extend shelf life and freshness. However, excessive intake of exogenous HSO3- can lead to abnormal HSO3- concentration levels in the body, causing cardiovascular and respiratory diseases. This highlights the urgent need to develop a rapid and sensitive probe for the quantitative detection of HSO3- in foods and biosystems. In this study, we design and synthesize a novel HSO3- fluorescent probe named DCPD. Bioimaging experiments show that DCPD has good mitochondrial targeting and can be used to imaging the redox process of HSO3-/H2O2 in cells and tissue. In addition, DCPD has been used in detecting HSO3- in foods with satisfactory recoveries (98.62–105.06%), further demonstrating its compatibility and utility. Thus, the DCPD probe offers substantial promise for application in food analysis and the assessment of HSO3- concentrations in biological systems.

Graphical Abstract