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Rationale <p>Cannabis use continues to increase globally, with a growing proportion of users exhibiting problematic patterns of use. Although neural differences in reward and inhibitory control systems are commonly reported in individuals who use cannabis relative to individuals not reporting cannabis use, findings using behavioural tasks are inconsistent. This is possibly due to lack of differentiation between regular and more problematic patterns of use.</p> Objectives <p>This study investigated whether inhibitory control performance and associated prefrontal and orbitofrontal activation differed across CUDIT-R-stratified levels of CUD risk.</p> Methods <p>Participants (<i>N</i> = 81) were divided into three groups based on CUDIT-R scores: 30 high-CUD-risk individuals who use cannabis (≥ 12), 21 low-CUD-risk individuals who use cannabis (&lt; 8), and 30 individuals not reporting cannabis use. Individuals with a current substance use disorder, including cannabis use disorder, were excluded from participation. All completed a cannabis-cue specific Stop-Signal Task (SST) while functional near-infrared spectroscopy (fNIRS) was used to measure oxygenated (oxyHb) and deoxygenated haemoglobin (deoxyHb) concentrations in the prefrontal cortices. Behavioural performance and neural activation were compared across groups.</p> Results <p>No significant behavioural or neural differences were found between the groups.</p> Conclusions <p>The study found no evidence of impaired inhibitory control or differential prefrontal activation across CUDIT-R-stratified levels of CUD risk. The results suggest incorporating further diagnostic stratification, multimodal imaging, and ecologically valid methods in future research to better characterise cannabis-related neural adaptations and inform clinical practice.</p>

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No differences in inhibitory control or prefrontal activation during a cannabis cue stop-signal task across CUDIT-R-defined CUD-risk groups

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月3日

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  • Christopher R. Pickering,
  • Valentina Lorenzetti,
  • Andrew Jones,
  • Martin Guest,
  • Paul Christiansen,
  • Carl A. Roberts

摘要

Rationale

Cannabis use continues to increase globally, with a growing proportion of users exhibiting problematic patterns of use. Although neural differences in reward and inhibitory control systems are commonly reported in individuals who use cannabis relative to individuals not reporting cannabis use, findings using behavioural tasks are inconsistent. This is possibly due to lack of differentiation between regular and more problematic patterns of use.

Objectives

This study investigated whether inhibitory control performance and associated prefrontal and orbitofrontal activation differed across CUDIT-R-stratified levels of CUD risk.

Methods

Participants (N = 81) were divided into three groups based on CUDIT-R scores: 30 high-CUD-risk individuals who use cannabis (≥ 12), 21 low-CUD-risk individuals who use cannabis (< 8), and 30 individuals not reporting cannabis use. Individuals with a current substance use disorder, including cannabis use disorder, were excluded from participation. All completed a cannabis-cue specific Stop-Signal Task (SST) while functional near-infrared spectroscopy (fNIRS) was used to measure oxygenated (oxyHb) and deoxygenated haemoglobin (deoxyHb) concentrations in the prefrontal cortices. Behavioural performance and neural activation were compared across groups.

Results

No significant behavioural or neural differences were found between the groups.

Conclusions

The study found no evidence of impaired inhibitory control or differential prefrontal activation across CUDIT-R-stratified levels of CUD risk. The results suggest incorporating further diagnostic stratification, multimodal imaging, and ecologically valid methods in future research to better characterise cannabis-related neural adaptations and inform clinical practice.