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Rationale <p>Limited data exist on the potential of nicotine pouches to help smokers quit.</p> Objectives <p>To examine nicotine delivery from and user reactions to a popular nicotine pouch.</p> Methods <p>Twenty smokers provided data after overnight abstinence, first after smoking a cigarette and then, a week or more later, after using 9&#xa0;mg nicotine ZYN pouch. Blood samples were collected before and 2, 4, 6, 8, 10 and 30&#xa0;min (and also 60&#xa0;min in the pouch condition) after starting product use. Participants also rated their urges to smoke at 5, 10, 15 and 30 minutes, and provided ratings of pouch characteristics at the end of the session. </p> Results <p>Pouches delivered nicotine more slowly than cigarettes (Tmax 30&#xa0;min vs. 6&#xa0;min, z =-3.93, <i>p</i> &lt; 0.001), though nicotine levels from pouches reached 13 ng/ml within 10&#xa0;min. Cmax was higher than from cigarettes (27.9 vs. 19.5 ng/ml, t (19) =-2.17, <i>p</i> = 0.043). Both products had the same effect on reducing urges to smoke over 30&#xa0;min although cigarettes were more effective at 5&#xa0;min. With pouches, urges to smoke remained low at 60&#xa0;min. Pouches were rated as delivering more nicotine and being less pleasant than cigarettes; but as effective and as fast in reducing urges to smoke. Three participants who were light smokers experienced nausea and one vomited.</p> Conclusions <p>The initial appeal of pouches to smokers is likely to be more limited than the appeal of products that resemble smoking more closely, and ZYN pouches with 9&#xa0;mg of nicotine may be too strong for light smokers. However, in terms of nicotine delivery and effects on urges to smoke, pouches have good potential to provide effective replacement for smoking.</p>

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Nicotine delivery from and user reactions to nicotine pouches compared to cigarettes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月12日

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  • Dunja Przulj,
  • Katie Myers Smith,
  • Hayden McRobbie,
  • Francesca Pesola,
  • Irina Ananina,
  • Daniella Ladmore,
  • Peter Hajek

摘要

Rationale

Limited data exist on the potential of nicotine pouches to help smokers quit.

Objectives

To examine nicotine delivery from and user reactions to a popular nicotine pouch.

Methods

Twenty smokers provided data after overnight abstinence, first after smoking a cigarette and then, a week or more later, after using 9 mg nicotine ZYN pouch. Blood samples were collected before and 2, 4, 6, 8, 10 and 30 min (and also 60 min in the pouch condition) after starting product use. Participants also rated their urges to smoke at 5, 10, 15 and 30 minutes, and provided ratings of pouch characteristics at the end of the session.

Results

Pouches delivered nicotine more slowly than cigarettes (Tmax 30 min vs. 6 min, z =-3.93, p < 0.001), though nicotine levels from pouches reached 13 ng/ml within 10 min. Cmax was higher than from cigarettes (27.9 vs. 19.5 ng/ml, t (19) =-2.17, p = 0.043). Both products had the same effect on reducing urges to smoke over 30 min although cigarettes were more effective at 5 min. With pouches, urges to smoke remained low at 60 min. Pouches were rated as delivering more nicotine and being less pleasant than cigarettes; but as effective and as fast in reducing urges to smoke. Three participants who were light smokers experienced nausea and one vomited.

Conclusions

The initial appeal of pouches to smokers is likely to be more limited than the appeal of products that resemble smoking more closely, and ZYN pouches with 9 mg of nicotine may be too strong for light smokers. However, in terms of nicotine delivery and effects on urges to smoke, pouches have good potential to provide effective replacement for smoking.