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<p>This study examined patients who underwent solid organ transplantation (SOT) within a large healthcare system in Taiwan, with the objective of comparing the risks of adverse outcomes, specifically end-stage renal disease (ESRD) and mortality. The study aimed to assess whether type 2 diabetes mellitus (T2DM), occurring either before or after SOT, serves as a prognostic factor in this particular population.&#xa0;The study cohort comprised 3,675 non-T2DM patients, 2,261 patients with pre-existing T2DM, and 358 patients who developed T2DM post-SOT. Univariable and multivariable Cox proportional hazards regression models were employed to evaluate the impact of risk factors on the likelihood of developing ESRD or death, with results expressed as hazard ratios (HR) accompanied by 95% confidence intervals (CI).&#xa0;The group with pre-existing T2DM exhibited a higher risk of ESRD and mortality compared to the non-T2DM group (adjusted HR (aHR) = 2.14, 95% CI (1.44, 3.19); aHR = 1.37, 95% CI (1.12, 1.68)). Conversely, the post-SOT T2DM group did not demonstrate an increased risk of ESRD and mortality relative to the non-T2DM group (aHR = 0.95, 95% CI (0.45, 1.59); aHR = 1.23, 95% CI (0.93, 1.61)). Additionally, the risk of ESRD and death was elevated in the pre-existing T2DM group within the liver transplant cohort (aHR = 2.07, 95% CI (1.28, 3.35); aHR = 1.35, 95% CI (1.07,&#xa0;1.71)).&#xa0;Pre-SOT T2DM may serve as a predictor of ESRD and all-cause mortality, particularly for those undergoing liver transplantation.</p>

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Pre-existing but not post-solid organ transplantation diabetes mellitus predicts end stage renal disease and mortality

  • 期刊论文

  • 发表日期：

    2025年8月13日

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  • Wei-Syun Hu,
  • Cheng-Li Lin

摘要

This study examined patients who underwent solid organ transplantation (SOT) within a large healthcare system in Taiwan, with the objective of comparing the risks of adverse outcomes, specifically end-stage renal disease (ESRD) and mortality. The study aimed to assess whether type 2 diabetes mellitus (T2DM), occurring either before or after SOT, serves as a prognostic factor in this particular population. The study cohort comprised 3,675 non-T2DM patients, 2,261 patients with pre-existing T2DM, and 358 patients who developed T2DM post-SOT. Univariable and multivariable Cox proportional hazards regression models were employed to evaluate the impact of risk factors on the likelihood of developing ESRD or death, with results expressed as hazard ratios (HR) accompanied by 95% confidence intervals (CI). The group with pre-existing T2DM exhibited a higher risk of ESRD and mortality compared to the non-T2DM group (adjusted HR (aHR) = 2.14, 95% CI (1.44, 3.19); aHR = 1.37, 95% CI (1.12, 1.68)). Conversely, the post-SOT T2DM group did not demonstrate an increased risk of ESRD and mortality relative to the non-T2DM group (aHR = 0.95, 95% CI (0.45, 1.59); aHR = 1.23, 95% CI (0.93, 1.61)). Additionally, the risk of ESRD and death was elevated in the pre-existing T2DM group within the liver transplant cohort (aHR = 2.07, 95% CI (1.28, 3.35); aHR = 1.35, 95% CI (1.07, 1.71)). Pre-SOT T2DM may serve as a predictor of ESRD and all-cause mortality, particularly for those undergoing liver transplantation.