Scholarlink

<p>HeLa cervical cancer cells exhibit high aggressiveness and proliferation, highlighting the need for novel therapies. Nanocomposite synthesis offers a promising approach due to its enhanced bioavailability, targeted delivery, and selective cytotoxicity. Thus, carboxymethyl cellulose (CMC) and D-carvone (Dcar)-coated strontium oxide (SrO<sub>2</sub>) (SrO<sub>2</sub>-CMC-Dcar) nanocomposite were synthesized using a wet chemical method. Structural and morphological characterization using XRD, FTIR, PL spectroscopy, DLS, HRTEM, and XPS confirmed the successful synthesis of the nanocomposite. XRD analysis revealed that the crystallite sizes of SrO<sub>2</sub> and SrO<sub>2</sub>-CMC-Dcar were 38&#xa0;nm and 29&#xa0;nm, respectively. PL spectra revealed prominent green emission at 516, 524, and 535&#xa0;nm, indicating that oxygen vacancies are associated with ROS generation. DLS analysis revealed that pure SrO<sub>2</sub> exhibited a particle size distribution of 128.7&#xa0;nm, while the SrO<sub>2</sub>-CMC-Dcar nanocomposite showed an increased size of 244.80&#xa0;nm. The nanocomposite demonstrated an enhanced antimicrobial activity against <i>MRSA</i> and <i>Candida albicans</i> when compared to SrO<sub>2</sub> alone. Furthermore, MTT assay results revealed that the SrO<sub>2</sub>–CMC–Dcar composite significantly decreased HeLa cell viability to 11.94%, and the IC<sub>50</sub> value was found to be 50.2 and 39.7 for SrO<sub>2</sub> and nanocomposite SrO<sub>2</sub>-CMC-Dcar, respectively, confirming it enhanced anticancer potential. In addition, the SrO<sub>2</sub>-CMC-Dcar nanocomposite exhibited enhanced antioxidant properties demonstrated by DPPH free radical scavenging assays. These findings suggest that the SrO<sub>2</sub>-CMC-Dcar nanocomposite holds promise for therapeutic applications in combating cancer, microbial infections, and oxidative stress.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Design and characterization of SrO2-CMC-Dcar nanocomposite with enhanced antimicrobial, anticancer, and antioxidant activities

  • 期刊论文

  • 发表日期：

    2025年7月9日

查看全文
  • Sanketsinh Thakore,
  • Rajat Saini,
  • Ravi kant Kushwaha,
  • Asha K.,
  • Indumathi Thangavelu,
  • AbdulAziz A. AlGhamdi,
  • Srinivas Tadepalli

摘要

HeLa cervical cancer cells exhibit high aggressiveness and proliferation, highlighting the need for novel therapies. Nanocomposite synthesis offers a promising approach due to its enhanced bioavailability, targeted delivery, and selective cytotoxicity. Thus, carboxymethyl cellulose (CMC) and D-carvone (Dcar)-coated strontium oxide (SrO2) (SrO2-CMC-Dcar) nanocomposite were synthesized using a wet chemical method. Structural and morphological characterization using XRD, FTIR, PL spectroscopy, DLS, HRTEM, and XPS confirmed the successful synthesis of the nanocomposite. XRD analysis revealed that the crystallite sizes of SrO2 and SrO2-CMC-Dcar were 38 nm and 29 nm, respectively. PL spectra revealed prominent green emission at 516, 524, and 535 nm, indicating that oxygen vacancies are associated with ROS generation. DLS analysis revealed that pure SrO2 exhibited a particle size distribution of 128.7 nm, while the SrO2-CMC-Dcar nanocomposite showed an increased size of 244.80 nm. The nanocomposite demonstrated an enhanced antimicrobial activity against MRSA and Candida albicans when compared to SrO2 alone. Furthermore, MTT assay results revealed that the SrO2–CMC–Dcar composite significantly decreased HeLa cell viability to 11.94%, and the IC50 value was found to be 50.2 and 39.7 for SrO2 and nanocomposite SrO2-CMC-Dcar, respectively, confirming it enhanced anticancer potential. In addition, the SrO2-CMC-Dcar nanocomposite exhibited enhanced antioxidant properties demonstrated by DPPH free radical scavenging assays. These findings suggest that the SrO2-CMC-Dcar nanocomposite holds promise for therapeutic applications in combating cancer, microbial infections, and oxidative stress.