<p>The Rudolf Buchheim Award is an annual prize awarded by the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) to recognize outstanding work from young researchers in the fields of pharmacology and toxicology. The 2025 Rudolf Buchheim Award recognizes advancements in understanding drug-induced liver injury. This year’s recipient, Rebekka Lambrecht, investigated acetaminophen (APAP)-induced liver toxicity in the lab of Prof. Thomas Brunner at the University of Konstanz. Her research highlights the role of mitochondrial damage and oxidative stress in driving hepatocyte death, revealing that metabolic reprogramming can enhance cell survival and demonstrating the mechanism APAP toxicity inhibits apoptosis and shifts cells toward necrosis. Her findings provide a deeper understanding of APAP hepatotoxicity and suggest potential therapeutic strategies aimed at stabilizing mitochondrial function and mitigating oxidative stress in drug-induced liver injury.</p>